GW1929
Catalog No.
A3453
Potent PPARγ agonist
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GW1929 (CAS 196808-24-9) is a non-thiazolidinedione agonist selective for peroxisome proliferator-activated receptor gamma (PPARγ), a nuclear hormone receptor prominently expressed across multiple brain regions. GW1929 inhibits L-type voltage-dependent calcium channel (VDCC) currents (IC50: 5.0 μM), resulting in relaxation of resistance arteries. In vivo experiments demonstrate that GW1929 administration reduces neuronal injury following focal cerebral ischemia-reperfusion, associated with decreased inflammatory mediators (MMP-9, COX-2, iNOS, TNFα, IL-6) and apoptotic cell death. GW1929 serves as a valuable tool compound for neuroinflammation and neuroprotection research.
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 495.57 |
| Cas No. | 196808-24-9 |
| Formula | C30H29N3O4 |
| Synonyms | GW 1929;GW-1929 |
| Solubility | ≥ 35 mg/mL in DMSO |
| Chemical Name | 2-((2-benzoylphenyl)amino)-3-(4-(2-(methyl(pyridin-2-yl)amino)ethoxy)phenyl)propanoic acid |
| SDF | Download SDF |
| Canonical SMILES | CN(C1=CC=CC=N1)CCOC2=CC=C(CC(NC3=CC=CC=C3C(C4=CC=CC=C4)=O)C(O)=O)C=C2 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
- View current batch:
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
