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GW1929

Catalog No.
A3453
Potent PPARγ agonist
Grouped product items
SizePriceStock Qty
5mg
$105.00
Ship with 5-10 days
25mg
$463.00
Ship with 5-10 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

GW1929 (CAS 196808-24-9) is a non-thiazolidinedione agonist selective for peroxisome proliferator-activated receptor gamma (PPARγ), a nuclear hormone receptor prominently expressed across multiple brain regions. GW1929 inhibits L-type voltage-dependent calcium channel (VDCC) currents (IC50: 5.0 μM), resulting in relaxation of resistance arteries. In vivo experiments demonstrate that GW1929 administration reduces neuronal injury following focal cerebral ischemia-reperfusion, associated with decreased inflammatory mediators (MMP-9, COX-2, iNOS, TNFα, IL-6) and apoptotic cell death. GW1929 serves as a valuable tool compound for neuroinflammation and neuroprotection research.

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt495.57
Cas No.196808-24-9
FormulaC30H29N3O4
SynonymsGW 1929;GW-1929
Solubility≥ 35 mg/mL in DMSO
Chemical Name2-((2-benzoylphenyl)amino)-3-(4-(2-(methyl(pyridin-2-yl)amino)ethoxy)phenyl)propanoic acid
SDFDownload SDF
Canonical SMILESCN(C1=CC=CC=N1)CCOC2=CC=C(CC(NC3=CC=CC=C3C(C4=CC=CC=C4)=O)C(O)=O)C=C2
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

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Chemical structure

GW1929