Aurora Kinase
Aurora kinases are a family of serine-threonine kinases of three highly homologous members, including aurora A kinase, aurora B kinase and aurora C kinase, which are responsible for chromosome assembly and segregation during mitosis. Aurora kinases are characterized by two domains: a regulatory domain in the NH2 terminus and a catalytic domain in the COOH terminus, in which an A-Box and a D-Box found correspondingly in each domain are responsible for protein degradation. Aurora A kinase plays an important role in centrosome function and duplication, mitotic entry and bipolar spindle assembly; while Aurora B kinase is the catalytic component of the chromosomal passenger complex regulating the accurate segregation of the chromatids at mitosis, histone modification and cytokinesis. Aurora C kinase is less studied and expressed restrictedly in the testes.
- A4488 Anacardic acidTarget: Histone Acetyltransferases (HATs)Summary: HAT inhibitor
- A4489 TC-A 2317 hydrochlorideTarget: Aurora KinasesSummary: Aurora kinase A inhibitor,potent and selective
- A8807 MK-8745Target: Aurora KinasesSummary: Aurora A inhibitor,potent and selective
- B6014 BI-847325Summary: dual inhibitor of MEK and Aurora kinases
- C3823 Phthalazinone pyrazoleSummary: Aurora A kinase inhibitor
- A4110 MLN8237 (Alisertib)6 CitationSummary: Aurora A Kinase inhibitor, Potent and selective
- A4111 VX-680 (MK-0457,Tozasertib)Target: Aurora KinasesSummary: Aurora kinase inhibitor
- A4112 Barasertib (AZD1152-HQPA)3 CitationTarget: Aurora KinasesSummary: Aurora Kinase B inhibitor, Potent and selective
- A4113 ZM 447439Target: Aurora Kinases|MEK|Src|LckSummary: Aurora Kinase inhibitor,potent and selective
- A4129 ENMD-2076 L-(+)-Tartaric acidSummary: Aurora kinases inhibitor