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c-Kit

C-kit is a type of receptor tyrosine kinase and a type of tumor marker, also called CD117 and stem cell factor receptor.

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  1. ISCK03
    Catalog No. :
    C3152
    inhibitor of SCF-mediated c-kit activation
  2. Imatinib (STI571)
    Catalog No. :
    B2171
    Protein-tyrosine kinase inhibitor
    Imatinib is an inhibitor of protein-tyrosine kinase with IC50 values of 0.1, 0.1 and 0.025μM, respectively against PDGF receptor, c-Kit and Abl .
  3. OSI-930
    Catalog No. :
    A2838
    Inhibitor of Kit, KDR, Flt, CSF-1R, c-Raf and Lck

    OSI-930 is a novel, potent inhibitor of Flt1, kinase insert domain receptor (KDR), CSF-1R, Lck, c-Raf and activated receptor tyrosine kinases Kit with IC50 values of 8, 9, 15, 22, 41 and 80 nM, respectively .

  4. Imatinib Mesylate (STI571)
    Catalog No. :
    A1805
    Abl/c-kit/PDGFR inhibitor
    Imatinib mesylate is a tyrosine kinase inhibitor IC50 value of 100 nM, 100 nM, 600 nM for v-Abl, c-kit, PDGFR, respectively .
  5. Masitinib (AB1010)
    Catalog No. :
    A2942
    Tyrosine kinase inhibitor, potent and selective
    The stem cell factor receptor (KIT) is a therapeutic target for the cancer, mastocytosis, and inflammatory diseases treatment. Masitinib (AB1010) is a novel phenylaminothiazole-type tyrosine kinase inhibitor that targets KIT.
  6. Motesanib
    Catalog No. :
    A3632
    Inhibitor of Flk-1/Flt-4/PDGFR-/c-Kit
    Motesanib diphosphate (AMG-706) is a potent ATP-competitive inhibitor of VEGFR1/2/3 with IC50 of 2 nM/3 nM/6 nM, respectively
  7. Amuvatinib (MP-470, HPK 56)
    Catalog No. :
    A4237
    Tyrosine kinase inhibitor
    Amuvatinib (also known as MP-470 or HPK 56), a synthetic carbothioamide, is a novel and potent tyrosine kinase inhibitor, which exerts in vitro and in vivo activities against multiple targets including mutant KIT, platelet-derived growth factor receptor alpha (PDGFRα) and DNA repair.

7 Items

per page