Caspase
Caspases (cysteine-dependent aspartate specific ptotease) are a family of cysteine proteases that play an essential role in cell apoptosis. Caspases contain a conserved QACXG pentapeptide active site motif and are characterized by specificity for aspartic acid in the P1 position. The synthesis of caspases involves the activation of inactive proenzymes, which contain an N-terminal peptide (prodomain) together with two subunits (one small and one large), following cleavage at specific aspartate cleavage sites. Caspases can be classified into three subfamilies, due to phylogenetic analysis, including an ICE subfamily (caspases-1, -4 and -5), a CED-3/CPP32 subfamily (caspases-3, -6, -7, -8, -9 and -10) and an ICH-1/Nedd2 subfamily (caspase-2).
- A4016 Apoptosis Activator 2Summary: Indoledione caspase activator, cell-permeable
- A1901 Q-VD-OPh53 CitationTarget: CaspasesSummary: Cell-permeable, irreversible pan-caspase inhibitor
- A1904 Boc-D-FMK1 CitationTarget: CaspasesSummary: Pan-caspase inhibitor
- A1920 Z-DEVD-FMK12 CitationTarget: CaspasesSummary: Caspase-3 inhibitor
- A1921 Z-DQMD-FMK3 CitationTarget: CaspasesSummary: Caspase-3 inhibitor,cell-permeable
- A1922 Z-VDVAD-FMKSummary: Caspase-2 inhibitor
- A1923 Z-VEID-FMK2 CitationTarget: CaspasesSummary: Caspase-6 inhibitor
- A1924 Z-WEHD-FMK1 CitationSummary: Caspase 5 inhibitor,potent,cell-permeable and irreversible
- A1925 Caspase-3/7 Inhibitor I2 CitationTarget: CaspasesSummary: Caspase-3/7 inhibitor
- A1930 Apoptosis InhibitorSummary: Associate with caspase-3 inhibition