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ATM/ATR

ATM (ataxia telangiectasia mutated) and ATR (ATM- and Rad3-related) are two PIKKs (phosphatidylinositol 3-kinase-like kinases) that regulate the DNA damage response (DDR) pathways.

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  1. AZD0156
    Catalog No. :
    B7822
    ATM kinase inhibitor
  2. AZD6738
    Catalog No. :
    B6007
    ATR inhibitor
  3. VE-822
    Catalog No. :
    B1383
    ATR inhibitor

    VE-822 is an ATR inhibitor with an IC50 value of 0.019 μM.

  4. ETP-46464
    Catalog No. :
    A8626
    ATR inhibitor,potent and selective
    ETP-46464 is a cell-permeable quinoline-containing heterotricyclic compound that acts as a potent inhibitor against mTOR, ATR, DNA-PK, PI 3-Kα, and ATM (IC50 = 0.6, 14, 36, 170, and 545 nM, respectively).
  5. CP-466722
    Catalog No. :
    A8625
    ATM inhibitor,potent and reversible
    CP-466722 is rapidly reversible potential ATM kinase inhibitor.
  6. CGK733
    Catalog No. :
    A8624
    ATM/ATR inhibitor,potent and selective

    CGK733 is an inhibitor of kinase ATM and ATR with IC50 value of ~200 nM [1].

  7. KU-60019
    Catalog No. :
    A8336
    ATM kinase inhibitor,potent and selective

    KU-60019 is a selective inhibitor of the Ataxia telangiectasia (A-T) mutated (ATM) protein with an IC50 value of 6.3 nM. In literature report, KU-60019 radiosensitizes h-TERT-immortalized normal fibroblasts but not A-T fibroblasts, suggesting it is a specific ATM kinase radiosensitizer .

  8. VE-821
    Catalog No. :
    A2521
    ATR kinase inhibitor

    VE-821 is a potent, highly-selective, and ATP-competitive DNA damage response (DDR) kinase ATR inhibitor with Ki value of 13nM.

  9. KU 55933
    Catalog No. :
    A4605
    ATM inhibitor,potent and selective

    KU-55933 is a specific inhibitor of ATM kinase with IC50 value of 13 nM .

  10. AZ20
    Catalog No. :
    A3210
    ATR inhibitor,potent and selective

    AZ20 is a potent and selective inhibitor of ATR. AZ20 inhibits ATR immunoprecipitated from HeLa nuclear extracts with an IC50 value of 5 nM and ATR mediated phosphorylation of Chk1 in HT29 colorectal adenocarcinoma tumor cells with an IC50 value of 50 nM.

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