Calpains
Calpains (calcium-dependent papain-like enzymes) are a family of intracellular enzymes that consist of complex multi-domains and share a calcium-dependent cysteine protease core. With the development of human genome sequencing, a total of fifteen human calpain genes have been identified (CAPN1 to CAPN15). Calpain 1 (μ-calpain) and calpain 2 (m-calpain) are the two most abundant and well studied members of calpain family in mammals, which are heterodimers characterized by consisting of an isoform-specific large subunit (approximately 80 kDa) and a common small subunit (approximately 28 kDa). The large subunit consists of four domains, domain I (function not clear), domain II (cysteine protease domain), domain III (function not clear) and domain IV (Ca2+-binding domain); while the small subunit consists of two domains, domain V (N-terminal glycine-clustering hydrophobic region) and domain VI (C-terminal Ca2+-binding domain).
- A4411 CalpeptinSummary: Ca2+-dependent protease,calpain inhibitor
- A4412 MDL 28170Target: Cathepsins|CalpainsSummary: Calpain and cathepsin B inhibitor, selective
- A4413 PD 150606Target: CalpainsSummary: Non-peptide calpain inhibitor
- C5830 PD 145305Summary: selective inhibitor of calpains
- C5347 Calpain Inhibitor XIISummary: reversible and selective inhibitor of calpain I
- A8170 Z-FA-FMKTarget: cysteine proteaseSummary: Cysteine proteases inhibitor
- A2576 E-642 CitationTarget: Cathepsins|Calpains|PapainsSummary: Cysteine protease inhibitor,irriversible
- A2602 Calpain Inhibitor I, ALLN2 CitationTarget: Cathepsins|CalpainsSummary: Calpain I/II/ B/L inhibitor
- A2603 Calpain Inhibitor II, ALLM2 CitationSummary: Calpain inhibitor
- A2585 MG-13226 CitationTarget: ProteasomeSummary: Proteasome inhibitor, Cell permeable, reversible