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Histone Acetyltransferases

Histone acetyltransferases (HATs) are a diverse group of enzymes catalyzing a posttranslational modification of acetylation in which the acetyl group from the acetyl-CoA cofactor is transferred to the Nζ nitrogen of the target lysine side chain within histones. Based on the sequence divergence within the HAT domain, HATs is classified into at least five distinct families, including HAT1 family, Gcn5/PCAF family, MYST family, p300/CBP family and Rtt109 family. Despite the sequence divergence, a structurally conserved core region has been identified within each of the protein families, which contains a three-stranded β-sheet with a α—helix corresponding to the A and D regions of the Gcn5-related N-acetyltransferases (GNAT) proteins.

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  1. CTPB
    Catalog No. :
    C5773
    selective activator of the histone acetyltransferase (HAT) p300
  2. HAT Inhibitor II
    Catalog No. :
    C5000
    inhibitor of the histone acetyltransferase p300
  3. Butyrolactone 3
    Catalog No. :
    C3209
    histone acetyltransferase Gcn5 inhibitor
  4. CPTH2 (hydrochloride)
    Catalog No. :
    C3208
    inhibitor of HAT activity of Gcn5
  5. MCB-613
    Catalog No. :
    A8712
    stimulator of steroid receptor coactivator (SRC)
    4-ethyl-2,6-bis-pyridin-3-ylmethylene-cyclohexanone, is a novel and potent stimulator of p160 steroid receptor coactivators (SRCs).
  6. Garcinol
    Catalog No. :
    B4946
    Inhibitor of PCAF and p300 histone acetyltransferase (HAT) activity
  7. IWP 12
    Catalog No. :
    B4945
    Potent inhibitor of Porcupine (PORCN)
  8. Remodelin
    Catalog No. :
    B4887
    NAT10 inhibitor
    Remodelin is a potent inhibitor of NAT10 [1]
  9. L002
    Catalog No. :
    B7739
    p300 inhibitor
    New Product
  10. (R)-(+)-Etomoxir sodium salt
    Catalog No. :
    B7679
    carnitine palmitoyltransferase I (CPT1) inhibitor

    New Product

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