Histone Acetyltransferases
Histone acetyltransferases (HATs) are a diverse group of enzymes catalyzing a posttranslational modification of acetylation in which the acetyl group from the acetyl-CoA cofactor is transferred to the Nζ nitrogen of the target lysine side chain within histones. Based on the sequence divergence within the HAT domain, HATs is classified into at least five distinct families, including HAT1 family, Gcn5/PCAF family, MYST family, p300/CBP family and Rtt109 family. Despite the sequence divergence, a structurally conserved core region has been identified within each of the protein families, which contains a three-stranded β-sheet with a α—helix corresponding to the A and D regions of the Gcn5-related N-acetyltransferases (GNAT) proteins.
- C5773 CTPBSummary: selective activator of the histone acetyltransferase (HAT) p300
- C5000 HAT Inhibitor IISummary: inhibitor of the histone acetyltransferase p300
- C3209 Butyrolactone 3Summary: histone acetyltransferase Gcn5 inhibitor
- C3208 CPTH2 (hydrochloride)Summary: inhibitor of HAT activity of Gcn5
- A8712 MCB-613Target: SrcSummary: stimulator of steroid receptor coactivator (SRC)
- B4946 GarcinolSummary: Inhibitor of PCAF and p300 histone acetyltransferase (HAT) activity
- B4945 IWP 12Summary: Potent inhibitor of Porcupine (PORCN)
- B4887 RemodelinTarget: NAT10Summary: NAT10 inhibitor
- B7739 L002Summary: p300 inhibitor
- B7679 (R)-(+)-Etomoxir sodium saltSummary: carnitine palmitoyltransferase I (CPT1) inhibitor