Garcinol
Catalog No.
B4946
Inhibitor of PCAF and p300 histone acetyltransferase (HAT) activity
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Garcinol (CAS: 78824-30-3) is a polyisoprenylated benzophenone isolated from Garcinia indica, recognized primarily for its inhibitory activity on cholinesterases, with reported IC50 values of 0.66 μM (acetylcholinesterase, AChE) and 7.39 μM (butyrylcholinesterase, BChE). Garcinol also serves as an inhibitor of histone acetyltransferases (HATs), including p300/CBP-associated factor (PCAF; IC50 = 5 μM) and other HAT-related enzymes (IC50 = 7 μM), thereby influencing gene transcription and cellular proliferation. These biological actions underpin its research utilization in inflammation and oncology studies.
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 602.8 |
| Cas No. | 78824-30-3 |
| Formula | C38H50O6 |
| Solubility | Soluble in DMSO |
| Chemical Name | (1R,5R,7R)-3-(3,4-dihydroxybenzoyl)-4-hydroxy-8,8-dimethyl-5-((S)-5-methyl-2-(prop-1-en-2-yl)hex-4-en-1-yl)-1,7-bis(3-methylbut-2-en-1-yl)bicyclo[3.3.1]non-3-ene-2,9-dione |
| SDF | Download SDF |
| Canonical SMILES | O=C1[C@](C(O)=C2C(C3=CC(O)=C(O)C=C3)=O)(C[C@H](C/C=C(C)/C)C(C)=C)C[C@@H](C/C=C(C)/C)C(C)(C)[C@@]1(C/C=C(C)/C)C2=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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-
Purity ≥95.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
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