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Garcinol

Catalog No.
B4946
Inhibitor of PCAF and p300 histone acetyltransferase (HAT) activity
Grouped product items
SizePriceStock Qty
5mg
$83.00
Ship with 5-10 days
10mg
$126.00
Ship with 5-10 days
25mg
$293.00
Ship with 5-10 days
50mg
$498.00
Ship with 5-10 days
For scientific research use only and should not be used for diagnostic or medical purposes.

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Background

Garcinol (CAS: 78824-30-3) is a polyisoprenylated benzophenone isolated from Garcinia indica, recognized primarily for its inhibitory activity on cholinesterases, with reported IC50 values of 0.66 μM (acetylcholinesterase, AChE) and 7.39 μM (butyrylcholinesterase, BChE). Garcinol also serves as an inhibitor of histone acetyltransferases (HATs), including p300/CBP-associated factor (PCAF; IC50 = 5 μM) and other HAT-related enzymes (IC50 = 7 μM), thereby influencing gene transcription and cellular proliferation. These biological actions underpin its research utilization in inflammation and oncology studies.

Product Citation

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt602.8
Cas No.78824-30-3
FormulaC38H50O6
SolubilitySoluble in DMSO
Chemical Name(1R,5R,7R)-3-(3,4-dihydroxybenzoyl)-4-hydroxy-8,8-dimethyl-5-((S)-5-methyl-2-(prop-1-en-2-yl)hex-4-en-1-yl)-1,7-bis(3-methylbut-2-en-1-yl)bicyclo[3.3.1]non-3-ene-2,9-dione
SDFDownload SDF
Canonical SMILESO=C1[C@](C(O)=C2C(C3=CC(O)=C(O)C=C3)=O)(C[C@H](C/C=C(C)/C)C(C)=C)C[C@@H](C/C=C(C)/C)C(C)(C)[C@@]1(C/C=C(C)/C)C2=O
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

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Chemical structure

Garcinol

Related Biological Data

Garcinol

Related Biological Data

Garcinol

Related Biological Data

Garcinol

Related Biological Data

Garcinol