Neostigmine Bromide
Neostigmine bromide is a reversible inhibitor of acetylcholinesterase.[1]
AChE (acetylcholinesterase) is a hydrolase that hydrolyzes the neurotransmitter acetylcholine at the neuromuscular junction and cholinergic synaspe. It terminates the signal transductions and plays a role in neuronal apoptosis.
Neostigmine bromide is a quaternary amine that blocked cholinesterase activity to extend and enhance the muscarinic and nicotinic effects of acetylcholine. It is implicated for the treatment of primary open-angle glaucoma, postoperative urinary retention, paralytic ileus, myasthenia gravis etc. It is also reported to be an adjuvant to local anaesthetics and opioids for post-surgical pain after gynaecological or abdominal surgery. [1]
Reference:
[1] El-Kosasy AM, Nebsen M, Abd El-Rahman MK, Salem MY, El-Bardicy MG. Comparative study of 2-hydroxy propyl beta cyclodextrin and calixarene as ionophores in potentiometric ion-selective electrodes for neostigmine bromide. Talanta. 2011 Aug 15;85(2):913-8.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 303.2 |
| Cas No. | 114-80-7 |
| Formula | C12H19N2O2·Br |
| Solubility | ≥15.16 mg/mL in H2O; ≥29.2 mg/mL in EtOH; ≥45.3 mg/mL in DMSO |
| Chemical Name | [3-(dimethylcarbamoyloxy)phenyl]-trimethylazanium;bromide |
| SDF | Download SDF |
| Canonical SMILES | CN(C)C(Oc1cc([N+](C)(C)C)ccc1)=O.[Br-] |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
