P450
Cytochrome P450 are a family of heme-containing monoxygenases catalyzing the metabolism of xenobiotics in the body where P450 enzymes use O2 and two electrons provided by NAD(P)H with the help of redox partner flavoproteins and iron-sulfur proteins to catalyze the monooxygenation of a variety of substrates. Based on how electrons from NAD(P)H are delivered to the catalytic site, P450 enzymes are divided into four classes, including Class I requiring both an FAD-containing reductase and an iron sulfur redoxin, Class II requiring only an FAD/FMN-containg P450 reductase, Class III requiring no electron donor and Class IV requiring electrons directly from NAD(P)H.
- A8202 Abiraterone acetateTarget: Cytochrome P450 (CYP450)Summary: Cytochrome p450 17a1 inhibitor
- A4240 Abiraterone1 CitationSummary: Potent CYP17 inhibitor
- A4308 AlizarinSummary: Chelator for calcium,used to stain calcium deposites,Alizarin complexone is used for bone staining to study bone remodeling
- A4311 PF-4981517Summary: CYP3A4 inhibitor,potent and selective
- A4316 KetoconazoleTarget: Cytochrome P450 (CYP450)Summary: Inhibitor of cyclosporine oxidase and testosterone 6 beta-hydroxylase
- A4318 AvasimibeTarget: Acyl coenzyme A: cholesterol acyltransferasesSummary: ACAT inhibitor,orally bioavailable
- C3414 (S)-MephenytoinSummary: substrate of the cytochrome P450 (CYP) isoform CYP2C19
- C3471 Omeprazole sulfoneSummary: CYP2C19 inhibitor
- C3560 SKF 525A (hydrochloride)Summary: cytochrome P (CYP)450 inhibitor
- C4131 SulfaphenazoleSummary: CYP2C9 inhibitor