P450
Cytochrome P450 are a family of heme-containing monoxygenases catalyzing the metabolism of xenobiotics in the body where P450 enzymes use O2 and two electrons provided by NAD(P)H with the help of redox partner flavoproteins and iron-sulfur proteins to catalyze the monooxygenation of a variety of substrates. Based on how electrons from NAD(P)H are delivered to the catalytic site, P450 enzymes are divided into four classes, including Class I requiring both an FAD-containing reductase and an iron sulfur redoxin, Class II requiring only an FAD/FMN-containg P450 reductase, Class III requiring no electron donor and Class IV requiring electrons directly from NAD(P)H.
- C3414 (S)-MephenytoinSummary: substrate of the cytochrome P450 (CYP) isoform CYP2C19
- C3471 Omeprazole sulfoneSummary: CYP2C19 inhibitor
- C3560 SKF 525A (hydrochloride)Summary: cytochrome P (CYP)450 inhibitor
- C4131 SulfaphenazoleSummary: CYP2C9 inhibitor
- C4253 RhapontigeninSummary: inactivator of cytochrome P450 1A1 with antioxidant and anti-cancer activity
- C4429 4-phenyl-5-methyl-1,2,3-ThiadiazoleSummary: CYP2B4 and CYP2E1 inhibitor
- C4647 β-NicotyrineSummary: cytochrome P450 (CYP) isoforms, CYP2A6 and CYP2A13 inhibitor
- C5076 UniconazoleSummary: cytochrome P450 707As inhibitor
- C5344 HET0016Summary: inhibitor of 20-HETE formation
- B1240 (+)-KetoconazoleSummary: Potent inhibitor of cytochrome P450c17