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Free Fatty Acid Receptors

FFAR1 (GPR40) is a G protein-coupled receptor for medium and long chain saturated and unsaturated fatty acids. It plays a role in glucose homeostasis, insulin secretion and bone homeostasis etc.

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  1. GSK 137647
    Catalog No. :
    B7793
    FFA4/GPR120 agonist
    Potent and selective FFA4 (GPR120) agonist (pEC50 values are 6.3, 6.2 and 6.1 at the human, mouse and rat receptor, respectively). Exhibits ≥100-fold selectivity against a panel of 61 targets including FFA1, FFA2 and FFA3. Enhances glucose-stimulated insulin secretion in MIN6 cells. Induces intracellular calcium accumulation in U2OS cells; this activity is inhibited by AH 7614.
  2. AH 7614
    Catalog No. :
    B7792
    FFA4/GPR120 antagonist

    Selective free fatty acid receptor 4 (FFA4/GPR120) antagonist (pIC50 values are 7.1 and <4.6 for human FFA4 and FFA1 receptors respectively). Inhibits linoleic acid and GSK 137647A-induced intracellular calcium accumulation in U2OS osteosarcoma cells expressing the FFA4 receptor.

  3. 4-CMTB
    Catalog No. :
    B5669
    FFA2 agonist
    New Product
  4. AS 2034178
    Catalog No. :
    B7735
    GPR40 agonist
    Selective FFA1 (GPR40) agonist
  5. MEDICA 16
    Catalog No. :
    B7691
    Free fatty acid 1 (FFA1/GPR40) receptor agonist
    New Product
  6. TUG 424
    Catalog No. :
    B7499
    FFA1 (GPR40) agonist
    New Product
  7. GSK1292263
    Catalog No. :
    A8439
    Novel GPR119 agonist
    GSK1292263 is a novel GPR119 receptor agonist used for the treatment of type 2 diabetes.
  8. TAK-875
    Catalog No. :
    A8339
    GPR40 agonist
    TAK-875 is a potent, selective and orally bioavailable GPR40 agonist with EC50 of 0.072 μM. In treatment of diabetes.
  9. GW9508
    Catalog No. :
    A1709
    FFA1/GPR40 agonist,potent and selective

    GW9508 is a selective agonist of GPR40 and 120 with pEC50 value of 7.32 ± 0.03 and 5.46 ± 0.09, respectively .

  10. TUG-770
    Catalog No. :
    A3895
    FFA1/GPR40 agonist
    TUG-770 is a highly potent free fatty acid receptor 1 (FFA1/GPR40) agonist for treatment of type 2 diabetes.

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