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Proteases

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

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  1. Darunavir Ethanolate
    Catalog No. :
    B4950
    nonpeptidic HIV protease inhibitor
  2. Cathepsin Inhibitor 1
    Catalog No. :
    B2084
    Cathepsin inhibitor
    Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively.
  3. Z-VAD-FMK
    Catalog No. :
    A1902
    Cell-permeable, irreversible pan-caspase inhibitor

    Cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC50 = 0.0015 - 5.8 mM). Active in vivo.

  4. PD 145305
    Catalog No. :
    C5830
    selective inhibitor of calpains
  5. MMP-2 Inhibitor II
    Catalog No. :
    C5818
    irreversible inhibitor of MMP-2
  6. MMP-2 Inhibitor I
    Catalog No. :
    C5615
    reversible inhibitor of matrix metalloproteinase (MMP)-2
  7. MMP-2/MMP-9 Inhibitor I
    Catalog No. :
    C5598
    potent inhibitor of matrix metalloproteinase-2 (MMP-2) and MMP-9
  8. Chymostatin
    Catalog No. :
    C5589
    chymotryptase-like serine proteases inhibitor
  9. Tosyllysine Chloromethyl Ketone (hydrochloride)
    Catalog No. :
    C5839
    serine proteinases inhibitor
  10. Calpain Inhibitor XII
    Catalog No. :
    C5347
    reversible and selective inhibitor of calpain I

Items 1-10 of 249

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