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Thymidylate Synthase

Thymidylate synthase (TS) is an enzyme catalyzing the sole de novo pathway for the biosynthesis of deoxythymidine monophosphate (dTMP) in which deoxyuridine monophosphate (dUMP) is reductively methylated by 5,10-methylenetetrahydrofolate (CH2H4folate) with the generation of dTMP and dihydrofolate (H2folate). TS has been found in a wide range of sources, including bacteria, bacteriophage, yeast, viruses and vertebrates, where it is usually a dimer consisting of identical subunits (30 to 35 kDa each). However, protozoal TS is a bifunctional protein with dihydrofolate reductase (DHFR) on the same polypeptide chain, where TS and DHFR domains are located on the carboxy terminus and amino terminus respectively.

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  1. Nolatrexed (AG-337)
    Catalog No. :
    B5892
    Non-classical thymidylate synthase inhibitor
  2. Doxifluridine
    Catalog No. :
    B2092
    oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU)

    Doxifluridine is a thymidine phosphorylase activator for PC9-DPE2 cells with IC50 of 0.62 μM.

  3. Triflurdine (Viroptic)
    Catalog No. :
    A8542
    Anti-herpesvirus antiviral drug
    Trifluridine (also called trifluorothymidine or TFT) is an anti-herpesvirus antiviral drug, used primarily on the eye.
  4. Pemetrexed disodium hemipenta hydrate
    Catalog No. :
    A3707
    Antifolate and antimetabolite agent
    Pemetrexed is approved as a first-line treatment for advanced non-squamous non-small cell lung cancer (NSCLC) with cisplatin and as a single agent for second-line treatment or for patients who show no disease progression after four cycles of platinum-based doublet induction chemotherapy as maintenance therapy.
  5. Pemetrexed
    Catalog No. :
    A4390
    TS, DHFR,GARFT and AICARFT inhibitor

    Pemetrexed (also known as pemetrexed disodium) is a novel antifolate antimetabolite targeting multiple enzymes involved in both pyrimidine and purine synthesis.

5 Items

per page