HIV Integrase
Human immunodeficiency virus (HIV) integrase is a Mr 32000 protein encoded by the pol gene of HIV that catalyzes an essential step in the viral replicative cycle to integrate the viral DNA into the host DNA. HIV integrase catalyzes two temporally and spatially separated reactions, including process, where a CA dinucleotide from the 3’-ends of the double stranded viral DNA is cleaved by HIV integrase in cytoplasm generating a double-stranded DNA with a two-base overhang, and strand transfer, where the HIV integrase-and-DNA complex is transferred in to the nucleus. The most well studied HIV integrase is HIV-1 integrase characterized by containing three domains, including the N-terminal domain, the C-terminal domain and the core domain.
- A8566 GSK744 (S/GSK1265744)Summary: HIV integrase inhibitor, oral active and long-acting
- B5856 GSK1349572 sodiuM saltSummary: Next-generation HIV integrase (IN) inhibitor
- C4787 EquisetinSummary: HIV-1 integrase inhibitor
- B1122 NelfinavirSummary: HIV-1 protease inhibitor
- A4069 BMS-707035Target: HIV IntegrasesSummary: HIV-I integrase inhibitor,potent and specific
- A4070 Elvitegravir (GS-9137)Target: HIV IntegrasesSummary: HIV-1 integrase inhibitor,potent
- A4071 Fluorouracil (Adrucil)3 CitationTarget: Thymidylate SynthaseSummary: Antitumor agent;inhibitor of thymidylate synthase
- A4073 Raltegravir (MK-0518)1 CitationTarget: integraseSummary: HIV-1 integrase inhibitor
- A4074 S/GSK1349572Summary: HIV integrase inhibitor, novel and potent
- A3461 HIV-1 integrase inhibitorSummary: Uesful for anti-HIV