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HIV Integrase

Human immunodeficiency virus (HIV) integrase is a Mr 32000 protein encoded by the pol gene of HIV that catalyzes an essential step in the viral replicative cycle to integrate the viral DNA into the host DNA. HIV integrase catalyzes two temporally and spatially separated reactions, including process, where a CA dinucleotide from the 3’-ends of the double stranded viral DNA is cleaved by HIV integrase in cytoplasm generating a double-stranded DNA with a two-base overhang, and strand transfer, where the HIV integrase-and-DNA complex is transferred in to the nucleus. The most well studied HIV integrase is HIV-1 integrase characterized by containing three domains, including the N-terminal domain, the C-terminal domain and the core domain.

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  1. Equisetin
    Catalog No. :
    C4787
    HIV-1 integrase inhibitor
  2. GSK1349572 sodiuM salt
    Catalog No. :
    B5856
    Next-generation HIV integrase (IN) inhibitor
  3. Nelfinavir
    Catalog No. :
    B1122
    HIV-1 protease inhibitor
    Nelfinavir (brand name Viracept) is an antiretroviral drug used in the treatment of the human immunodeficiency virus (HIV).
  4. GSK744 (S/GSK1265744)
    Catalog No. :
    A8566
    HIV integrase inhibitor, oral active and long-acting
    GSK744 (S/GSK1265744) is a potential inhibitor of HIV integrase with IC50 value of 3 nM.
  5. Nelfinavir Mesylate
    Catalog No. :
    A3653
    HIV protease inhibitor,antiretroviral drug for HIV treatment
    Nelfinavir Mesylate is a potent inhibitor of HIV-1 protease [1].
  6. HIV-1 integrase inhibitor
    Catalog No. :
    A3461
    Uesful for anti-HIV
    HIV-1 integrase inhibitor is useful for anti-HIV, with IC50 value of 0.33 µM, which can target HIV-1 integrase and depress the activity in the treatment of HIV infection, AIDS, and other similar diseases characterized by integration of a retroviral genome into a host chromosome.
  7. S/GSK1349572
    Catalog No. :
    A4074
    HIV integrase inhibitor, novel and potent

    S/GSK1349572, also known as dolutegravir, is a novel and potent inhibitor of human immunodeficiency virus (HIV) integrase (IN) blocking the strand transfer of integration of the viral genome into the host cell’s DNA.

  8. Raltegravir (MK-0518)
    Catalog No. :
    A4073
    HIV-1 integrase inhibitor
    Raltegravir, formerly named MK-0518, is an HIV-1 integrase strand transfer inhibitor which has been shown to have activity against multidrug-resistant HIV-1 and both CCR5-trophic and CXCR4-trophic HIV-1 in vitro.
  9. MK-2048
    Catalog No. :
    A4072
    Integrase inhibitor for HIV-1,second generation

    MK-2048 is a second generation inhibitor of HIV-1 integrase with IC50 values of 0.075 μM and 0.08 μM for subtype B and subtype C integrase, respectively.

  10. Fluorouracil (Adrucil)
    Catalog No. :
    A4071
    Antitumor agent;inhibitor of thymidylate synthase

    Fluorouracil (Adrucil), a heterocyclic aromatic organic compound, is a potent anticancer agent widely used for the treatment of solid tumors, including breast cancer, ovarian cancer, head and neck cancer, and colon cancer. As an analogue of uracil, fluorouracil has a fluorine atom replacing the hydrogen atom at the C-5 position.

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