p53
The p53 tumor suppressor is a 53 kDa nuclear phosphoprotein of 393 amino acids that is encoded by the TP53 gene (20 kb with 11 exons and 10 introns) and characterized by the presence of several structural and functional domains, including a N-terminus, a central core domain, a C-terminal region, a strongly basic carboxyl-terminal regulatory domain, a nuclear localization signal sequence and three nuclear export signal sequence. The p53 is considered as a major “guardian of genome” for its activities in a wide range of cellular events, including cell-cycle regulation, induction of apoptosis, gene amplification, DNA recombination, chromosomal segregation and cellular senescence.
- A4455 PiperlongumineSummary: Inducer of cell-death
- A4456 PlumbaginSummary: Anticancer agent
- A4476 CP 31398 dihydrochlorideSummary: p53 stabilizer
- A4478 HLI 373Summary: Hdm2 ubiquitin ligase (E3) inhibitor
- A4479 MIRA-1Summary: Restorer of wild-type p53 conformation/cellular function
- A4481 PhiKan 083Target: p53Summary: p53 stabilizer
- A4483 PRIMA-1Target: p53Summary: BAX inhibitor
- A4485 RETRASummary: Antitumor agent
- A4486 SJ 172550Summary: MDMX inhibitor
- A4487 WR 1065Summary: P53/p21waf-1/MDM2 activator