RETRA

RETRA (CAS 1036069-26-7) is a small molecule that inhibits growth of tumor cells harboring mutant p53 by targeting the p53-p73 interaction pathway. RETRA functions by dissociating p73 from inhibitory complexes involving mutant p53, enabling p73-dependent apoptotic signaling. In vitro studies demonstrate selective growth inhibition (IC50 ~4 μM) in Ewing's sarcoma cells with mutant p53, accompanied by induction of p53-responsive genes and activation of caspases 3 and 7. In vivo, RETRA reduces growth of mutant p53-expressing tumors in mouse xenograft models, highlighting its potential utility for investigating therapeutic strategies targeting p53 mutation-related malignancies.