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RETRA

Catalog No.
A4485
Antitumor agent
Grouped product items
SizePriceStock Qty
10mg
$270.00
In stock
50mg
$1,137.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

RETRA (CAS 1036069-26-7) is a small molecule that inhibits growth of tumor cells harboring mutant p53 by targeting the p53-p73 interaction pathway. RETRA functions by dissociating p73 from inhibitory complexes involving mutant p53, enabling p73-dependent apoptotic signaling. In vitro studies demonstrate selective growth inhibition (IC50 ~4 μM) in Ewing's sarcoma cells with mutant p53, accompanied by induction of p53-responsive genes and activation of caspases 3 and 7. In vivo, RETRA reduces growth of mutant p53-expressing tumors in mouse xenograft models, highlighting its potential utility for investigating therapeutic strategies targeting p53 mutation-related malignancies.

Chemical Properties

Physical AppearanceOff-white solid
StorageDesiccate at RT
M.Wt269.33
Cas No.1036069-26-7
FormulaC11N11NO3S2
Solubility≥31.2 mg/mL in DMSO; ≥2.9 mg/mL in EtOH with ultrasonic; insoluble in H2O
Chemical Name2-((4,5-dihydrothiazol-2-yl)thio)-1-(3,4-dihydroxyphenyl)ethan-1-one
SDFDownload SDF
Canonical SMILESO=C(CSC1=NCCS1)C2=CC=C(C(O)=C2)O
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

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