RETRA
Catalog No.
A4485
Antitumor agent
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RETRA (CAS 1036069-26-7) is a small molecule that inhibits growth of tumor cells harboring mutant p53 by targeting the p53-p73 interaction pathway. RETRA functions by dissociating p73 from inhibitory complexes involving mutant p53, enabling p73-dependent apoptotic signaling. In vitro studies demonstrate selective growth inhibition (IC50 ~4 μM) in Ewing's sarcoma cells with mutant p53, accompanied by induction of p53-responsive genes and activation of caspases 3 and 7. In vivo, RETRA reduces growth of mutant p53-expressing tumors in mouse xenograft models, highlighting its potential utility for investigating therapeutic strategies targeting p53 mutation-related malignancies.
Physical Appearance | Off-white solid |
Storage | Desiccate at RT |
M.Wt | 269.33 |
Cas No. | 1036069-26-7 |
Formula | C11N11NO3S2 |
Solubility | ≥31.2 mg/mL in DMSO; ≥2.9 mg/mL in EtOH with ultrasonic; insoluble in H2O |
Chemical Name | 2-((4,5-dihydrothiazol-2-yl)thio)-1-(3,4-dihydroxyphenyl)ethan-1-one |
SDF | Download SDF |
Canonical SMILES | O=C(CSC1=NCCS1)C2=CC=C(C(O)=C2)O |
Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
