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S1P receptor

S1P (sphinogosine-1-phosphate) receptor is a G-protein coupled receptor that involved in regulation of cells proliferation, survival, motility and adhesion etc.

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  1. Ponesimod
    Catalog No. :
    B7809
    sphingosine-1-phosphate receptor 1 (S1P1) modulator
  2. Ozanimod (RPC1063)
    Catalog No. :
    B6038
    agonist of the sphingosine-1-phosphate receptor subtypes 1 and 5
  3. SKI II
    Catalog No. :
    B2226
    Sphingosine kinase(SK) inhibitor

    SKI II is an inhibitor of sphingosine kinase with IC50 value of 0.5μM.

  4. BAF312 (Siponimod)
    Catalog No. :
    B3225
    S1P agonist,potent and selective

    BAF312 is a potent and selective agonist of S1P with EC50 value of 0.39nM for S1P1 receptors and 0.98nM for S1P5 receptors, respectively .

  5. Fingolimod (FTY720)
    Catalog No. :
    A8548
    S1P receptors agonist

    Fingolimod is a mechanistically novel, orally bioavailable therapy for multiple sclerosis (MS) .

  6. PF-543
    Catalog No. :
    A3717
    SphK1 inhibitor,cell-permeate,potent and selective

    PF-543 is a novel cell-permeant inhibitor of SphK1. PF-543 inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform.

6 Items

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