Apoptosis Inducers
Apoptosis, a programmed cell death to eliminate damaged or abnormal cells, is a highly organized physiological process characterized by condensation of nuclear heterochromatin, cell shrinkage and loss of positional organization of organelles in the cytoplasm. Apoptosis inducers are a collection of compounds that are capable of inducing apoptosis in cells. Apoptosis has been extensively studied in numerous researches, where induction of apoptosis has been associated with a variety of events, including activation of p53 gene, transcription factor NF-κB or caspases. Apoptosis inducers have the potential to be incorporated into the management and therapy or prevention of cancer for their ability to induce apoptosis in cancer cells.
- A4188 2-Methoxyestradiol (2-MeOE2)2 CitationSummary: Apoptotic, antiproliferative and antiangiogenic agent
- A4234 TW-371 CitationTarget: Bcl-2|Bcl-xl|Mcl-1Summary: Bcl-2 inhibitor, inhibits Bcl-2,Bcl-XL and Mcl-1
- A3118 3,3'-DiindolylmethaneSummary: Anticancer and antineoplastic agent
- A3218 BAM7Summary: BAX activator,direct and selective
- A3237 Betulinic acidTarget: Aminopeptidases|Topoisomerases|HIVSummary: Anti-HIV and antitumor compound,pentacyclic triterpenoid
- A3265 BrassinolideSummary: Plant growth regulator
- A3278 Nonivamide (Capsaicin Analog)1 CitationTarget: TRP ChannelSummary: TRPV1 receptor agonist
- A3327 CostunolideTarget: FPTase|TelomerasesSummary: Apoptosis inducer
- A3335 Curcumin1 CitationTarget: Histone Deacetylases (HDACs)|Nrf2|Histone Acetyltransferases (HATs)|TyrosinasesSummary: Tyrosinase inhibitor
- A3424 Gambogic AcidSummary: Caspase activator and apoptosis inducer