Streptozocin
Antibiotic and antitumor agent. Alkylates DNA and induces diabetes mellitus via reduction of nicotinamide adenine dinucleotide in pancreatic β-cells in vivo.
- 1. Hailin Liu, Lian Zhou, et al. "PIEZO1 as a new target for hyperglycemic stress-induced neuropathic injury: The potential therapeutic role of bezafibrate." Biomed Pharmacother. 2024 Jul:176:116837. PMID: 38815290
- 2. Wenyu Dai, Rui Shu, et al. "Engineered Bio-Heterojunction Confers Extra- and Intracellular Bacterial Ferroptosis and Hunger-Triggered Cell Protection for Diabetic Wound Repair." Adv Mater. 2024 Mar;36(9):e2305277. PMID: 37526952
- 3. Ying Deng, Wenyi Zhu, et al. "Exendin-4 promotes bone formation in diabetic states via HDAC1-Wnt/β-catenin axis." Biochem Biophys Res Commun. 2021 Mar 12;544:8-14. PMID: 33516884
- 4. Ivana Stojanovic´, Katarina Šavikin, et al. "Pomegranate peel extract ameliorates autoimmunity in animal models of multiple sclerosis and type 1 diabetes." Journal of Functional Foods 35 (2017) 522–530.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 265.22 |
| Cas No. | 18883-66-4 |
| Formula | C8H15N3O7 |
| Solubility | ≥10.3 mg/mL in DMSO; ≥26.5 mg/mL in EtOH with gentle warming; ≥53.2 mg/mL in H2O |
| Chemical Name | 1-methyl-1-nitroso-3-[2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]urea |
| SDF | Download SDF |
| Canonical SMILES | O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1NC(N(N=O)C)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Cell experiment:[1] | |
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Cell lines |
A murine pancreatic β cell line, INS-1 |
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Reaction Conditions |
15 or 30 mM streptozocin for 1 h incubation |
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Applications |
Higher rates of apoptosis, as compared to necrosis, were observed when cells were exposed to 15 mM streptozocin for 1 h followed by a 24 h recovery period. Higher doses of streptozocin (30 mM) caused the cells to undergo necrosis (22%) as well as apoptosis (17%). Streptozotocin at low doses induced apoptosis and at high doses caused necrosis in INS-1 cells. |
| Animal experiment:[2] | |
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Animal models |
Male adult Holtzman rats |
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Dosage form |
50, 65 or 100 mg/kg A single intravenous injection |
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Applications |
Streptozotocin (65 mg/kg) resulted in rapid degranulation of β cells, accumulation of glycogen in the proximal convoluted tubules of the kidney, as well as development of cataracts in 4 months after streptozotocin treatment. At a higher dose of 100 mg/kg, streptozotocin produced lesions in the exocrine cells of the pancreas, and led to persistence of small, possibly secretory, granules in the Golgi zone of β cells in diabetic rats. Streptozotocin is often used to induce diabetes mellitus in experimental animals. |
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Note |
The technical data provided above is for reference only. |
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References: 1. Saini KS, Thompson C, Winterford CM, et al. Streptozotocin at low doses induces apoptosis and at high doses causes necrosis in a murine pancreatic beta cell line, INS-1. Biochemistry and Molecular Biology International, 1996, 39(6): 1229-1236. 2. Arison RN, Ciaccio EI, Glitzer MS, et al. Light and electron microscopy of lesions in rats rendered diabetic with streptozotocin. Diabetes, 1967, 16(1): 51-56. |
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