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Histone Demethylases

Histone demethylases are a diverse group of enzymes catalyzing a process to reverse histone methylation, in which methyl (CH3-) groups are removed from instead of being transferred to histone.  So far, two evolutionarily conserved histone demethylase families have been identified, including LSD demethylases and JMJC demethylases. LSD1 and LSD2 are two well-established members of LSD demethylase family, which catalyze demethylation through a flavin adenine dinucleotide (FAD)-dependent amine oxidation reaction. LSD1 has been found to demethylate H3K4mel, H3K4me2, H3K9me1, H3K9me2 and a few non-histone targets; while LSD2 has been found to demethylate only H3K4me1 and H3K4me2. Members of JMJC demethylase family is characterized by containing the catalytic JMJC domain, which demethylate substrates, including H3K4, H3K9, H3K27, H3K36 and H4K20, through a Fe(II)- and α-ketogutarate-dependent dioxygenase reaction.

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  1. OG-L002 HCl
    Catalog No. :
    A8766
    LSD1 inhibitor,potent and specific
    OG-L002 is a specific and potent inhibitor of lysine (K)-specific demethylase 1A (LSD1) with IC50 value of 20 nM.
  2. Bizine
    Catalog No. :
    C5162
    LSD1 inhibitor
  3. GSK-LSD1 (hydrochloride)
    Catalog No. :
    C4202
    LSD1 inhibitor
  4. RN-1 (hydrochloride)
    Catalog No. :
    C4247
    LSD1 inhibitor
  5. N-Oxalylglycine
    Catalog No. :
    C3095
    cell permeable inhibitor of α-ketoglutarate-dependent enzymes, including JMJD2A, JMJD2C, and JMJD2E.
  6. Lysine-specific Demethylase Inhibitor (1C)
    Catalog No. :
    C3630
    lysine-specific demethylase Inhibitor
  7. PBIT
    Catalog No. :
    C3584
    JARID1 family demethylases inhibitor
  8. CPI-455
    Catalog No. :
    B7811
    KDM5 inhibitor
  9. AS8351
    Catalog No. :
    B6084
    histone demethylase inhibitor
  10. 2,4-Pyridinedicarboxylic Acid
    Catalog No. :
    B5972
    Histone LSD inhibitor
    2,4-Pyridinedicarboxylic Acid

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