GSK J4 free base
Catalog No.
B5959
histone demethylase JMJD3/UTX inhibitor
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GSK J4 free base (CAS 1373423-53-0) is a small-molecule inhibitor targeting the histone demethylases JMJD3/KDM6B and UTX/KDM6A. It functions by preventing the demethylation of histone H3 lysine 27 (H3K27me3/me2), resulting in epigenetic modulation. In vitro assays demonstrate that GSK J4 inhibits JMJD3/KDM6B and UTX/KDM6A with micromolar potency. In cellular studies, it suppresses inflammatory responses, notably reducing TNF-α secretion in LPS-stimulated human primary macrophages, and induces apoptosis associated with endoplasmic reticulum stress. GSK J4 is commonly employed in epigenetic and inflammation-related disease research.
| Physical Appearance | White solid |
| Storage | Store at -20°C |
| M.Wt | 417.46 |
| Cas No. | 1373423-53-0 |
| Formula | C24H27N5O2 |
| Solubility | insoluble in H2O; ≥20.5 mg/mL in EtOH; ≥27.75 mg/mL in DMSO |
| Chemical Name | ethyl 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoate |
| SDF | Download SDF |
| Canonical SMILES | CCOC(CCNc1nc(-c2ncccc2)nc(N2CCc3ccccc3CC2)c1)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
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