cis-10-Heptadecenoic Acid

cis-10-Heptadecenoic Acid (CAS No.: 29743-97-3) is a naturally occurring cis-monounsaturated fatty acid predominantly identified as a minor component of ruminant lipids and studied for its biological activity in metabolic and signaling contexts. Functionally, this molecule participates in intracellular lipid metabolism, where it is processed by enzymes such as 2,4-dienoyl-CoA reductase and Delta3,Delta2-enoyl-CoA isomerase, contributing to the biosynthesis of polyhydroxy-chain alkanoates and related lipid intermediates. These metabolic transformations position cis-10-Heptadecenoic acid as a useful probe for investigating fatty acid oxidation pathways, lipid remodeling, and enzymatic regulation within mitochondrial and peroxisomal systems. In cellular studies, it has demonstrated inhibitory effects on the proliferation of certain leukemia cell lines and has been reported to attenuate lipopolysaccharide-induced tumor necrosis factor production in macrophages, suggesting modulatory roles in inflammatory signaling and immune responses, with activity typically observed in the micromolar concentration range. Owing to these properties, cis-10-Heptadecenoic acid is employed in biochemical and pharmacological research to explore lipid-mediated signaling pathways, enzyme function, and disease mechanisms, particularly in cancer biology and inflammation, with experimental concentrations varying according to specific model systems and study objectives.