cis-10-Nonadecenoic Acid

cis-10-Nonadecenoic Acid (CAS No.: 73033-09-7) is a long-chain monounsaturated fatty acid that functions as a bioactive lipid modulator with emerging relevance in cancer biology and inflammatory signaling research. Classified within the family of endogenous fatty acids, it has been investigated for its capacity to regulate cellular signaling pathways associated with proliferation, apoptosis, and immune responses. Experimental studies indicate that cis-10-Nonadecenoic Acid can inhibit tumor cell growth, exemplified by suppression of HL-60 leukemia cell proliferation at micromolar concentrations, and attenuate inflammatory responses by reducing lipopolysaccharide-induced tumor necrosis factor production in macrophages. Mechanistically, it is implicated in the modulation of enzyme activity and signaling cascades, including reported effects on p53-associated pathways, suggesting a role in the regulation of cell cycle progression and stress responses. As a lipid signaling regulator, it is widely utilized in in vitro cell-based assays and exploratory in vivo models to investigate tumor biology, metabolic regulation, and inflammation, as well as in early-stage drug discovery efforts targeting lipid-mediated signaling networks. Experimental concentrations and treatment regimens vary depending on the specific cellular context and study design, reflecting its use as a versatile research tool in biomedical investigations.