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5-Lipoxygenase

5-lipoxygenase catalyzes oxidation of AA at the 5-position to yield 5-HpETE and is a current target for pharmaceutical intervention in a number of diseases such as asthma, atherosclerosis and several cancers.

Items 1-10 of 11

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  1. Malotilate
    A2486 Malotilate
    Summary: Stimulates hepatocyte regeneration
      insoluble in H2O; ≥14.419 mg/mL
  2. Zileuton
    A5384 Zileuton
    Summary: 5-lipoxygenase (5-LOX) inhibitor, orally active
  3. ML355
    B8014 ML355
    Summary: 12-LOX inhibitor
      ≥42.7 mg/mL
  4. β-acetyl-Boswellic Acid
    C4123 β-acetyl-Boswellic Acid
    Summary: non-reducing inhibitor of 5-lipoxygenase (5-LO)
      ≤5 mg/mL
  5. U-73122
    B3422 U-73122
     1 Citation
    Target: PC-PLC
    Summary: inhibitor of phospholipase C, phospholipase A2, and 5-LO (5-lipoxygenase)
  6. BAY-X 1005
    B5447 BAY-X 1005
    Summary: Potent FLAP inhibitor
      <36.14 mg/mL
  7. Zileuton sodium
    B1207 Zileuton sodium
    Summary: 5-lipoxygenase and leukotrienes inhibitor
      Soluble in DMSO
  8. 2-TEDC
    B6391 2-TEDC
    Summary: 5-, 12-, and 15-lipoxygenase inhibitor
      Soluble to 100 mM in DMSO and to 25 mM in ethanol
  9. BW-B 70C
    B6680 BW-B 70C
    Summary: 5-Lipoxygenase inhibitor,potent and selective
      soluble in DMSO or ethanol
  10. MK 886
    B6684 MK 886
     1 Citation
    Summary: A FLAP and PPARα inhibitor, capable of inhibiting leukotriene biosynthesis and inducing apoptosis
      ≥15.1 mg/mL

Items 1-10 of 11

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