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Zileuton sodium

Catalog No.
B1207
5-lipoxygenase and leukotrienes inhibitor
Grouped product items
SizePriceStock Qty
10mg
$61.00
Ship with 10-15 days
50mg
$180.00
Ship with 10-15 days
100mg
$285.00
Ship with 10-15 days

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Email: [email protected]

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Background

Zileuton sodium is an inhibitor of 5-lipoxygenase, and thus inhibits leukotrienes(LTB4, LTC4, LTD4 and LTE4) formation with an IC50 value of 0.5μM [1].

Zileuton sodium has been reported to concentration-dependently inhibit the 5-lipoxygenase activity with an IC50 value of 0.5μM in RBL-1cell lysate. In addition, Zileuton sodium has been found to be a potent inhibitor of LTB formation with an IC50 value of 0.6μM. Furthermore, stimulated with A23187, Zileuton sodium has shown a dose-dependent reduction in LTB4 and 5-HETE generation in rat leukocyte with IC50 values of 0.38μM and 0.31μM, respectively. About 40-fold higher concentrations of Zileuton sodium also reduced the production of PGE2 with a IC50 of 16μM [1].

References:
[1] Carter GW1, Young PR, Albert DH, Bouska J, Dyer R, Bell RL, Summers JB, Brooks DW. 5-lipoxygenase inhibitory activity of zileuton. J Pharmacol Exp Ther. 1991 Mar; 256(3):929-37.

Chemical Properties

StorageStore at -20°C
M.Wt258.27
Cas No.118569-21-4
FormulaC11H11N2NaO2S
SolubilitySoluble in DMSO
SDFDownload SDF
Canonical SMILESCC(N([O-])C(O)=N)C1=CC2=CC=CC=C2S1.[Na+]
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size: ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Quality Control

Quality Control & MSDS

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Chemical structure

Zileuton sodium