IGF1R (insulin-Like growth factor 1 receptor) is a receptor tyrosine kinase that bind to insulin-like growth factor 1 with high affinity. It plays a vital role in in cell growth, cell survival and malignant transformation etc.
- NT157Catalog No. :B7808IRS-1/2 inhibitor, inhibits IGF-1R and STAT3 signaling pathway
- NVP-ADW742Catalog No. :B1584Selective IGF-1R inhibitorNVP-ADW742 is a novel inhibitor of IFG-1receptor (IGF-1R) kinase with the IC50 value of 0.17μM .
- LinsitinibCatalog No. :A8334IGF1R/IR inhibitor,potent and novel
Linsitinib (OSI-906) is a potent and novel small-molecule inhibitor inhibiting insulin receptor (IR) and IGF-1 receptor (IGF-1R) kinases with IC50 value of 75nM and 35nM, respectively.
- PQ 401Catalog No. :A2033IGF1R inhibitor,potent and cell-permeable
PQ401 is a novel, potent inhibitor of IGF-IR with IC50 of 12μM .
- NVP-AEW541Catalog No. :A2278IGF-IR inhibitor, novel, potent and selectiveNVP-AEW541 is a novel, potent and selective inhibitor of IGF-IR kinase with IC50 value of 0.086 M .
- GSK1904529ACatalog No. :A1302Selective IGF-1R/IR inhibitorGSK1904529A is a small-molecule inhibitor of the insulin-like growth factor-I receptor (IGF-IR) with IC50 value of 27 nM.
- BMS-754807Catalog No. :A1185IGF-1R/InsR inhibitor,potent and selectiveBMS-754807 is a potent and small molecular inhibitor which targets the IGF-1R/IR family kinases with Ki <2 nmol/L. The efficacy of BMS-754807 on normal tissues and tumor cell cycle is believed to be different from the effects of continuous inhibition by anti-IGF-1R antibodies.
- AG-1024Catalog No. :A2673Selective IGF-1R inhibitorAG1024 is an inhibitor of insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (IR) that specifically inhibits autophosphorylation of IGF-1R and IR with IC50 values of 7μM and 57 μm, respectively .
- BMS-536924Catalog No. :A2238IR/IGF-1R inhibitorBMS-536924 is a novel inhibitor of IGF-1R with IC50 value of 100nM .
- AXL1717Catalog No. :A3209IGF-1R inhibitor,orally activeAXL1717 (Picropodophyllotoxin) is a selective inhibitor of IGF-1R with IC50 value rangs from 0.24-0.33 μM .