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IGF1R (insulin-Like growth factor 1 receptor) is a receptor tyrosine kinase that bind to insulin-like growth factor 1 with high affinity. It plays a vital role in in cell growth, cell survival and malignant transformation etc.

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  1. NT157
    Catalog No. :
    IRS-1/2 inhibitor, inhibits IGF-1R and STAT3 signaling pathway
  2. NVP-ADW742
    Catalog No. :
    Selective IGF-1R inhibitor
    NVP-ADW742 is a novel inhibitor of IFG-1receptor (IGF-1R) kinase with the IC50 value of 0.17μM .
  3. Linsitinib
    Catalog No. :
    IGF1R/IR inhibitor,potent and novel

    Linsitinib (OSI-906) is a potent and novel small-molecule inhibitor inhibiting insulin receptor (IR) and IGF-1 receptor (IGF-1R) kinases with IC50 value of 75nM and 35nM, respectively.

  4. PQ 401
    Catalog No. :
    IGF1R inhibitor,potent and cell-permeable

    PQ401 is a novel, potent inhibitor of IGF-IR with IC50 of 12μM .

  5. NVP-AEW541
    Catalog No. :
    IGF-IR inhibitor, novel, potent and selective
    NVP-AEW541 is a novel, potent and selective inhibitor of IGF-IR kinase with IC50 value of 0.086 M .
  6. GSK1904529A
    Catalog No. :
    Selective IGF-1R/IR inhibitor
    GSK1904529A is a small-molecule inhibitor of the insulin-like growth factor-I receptor (IGF-IR) with IC50 value of 27 nM.
  7. BMS-754807
    Catalog No. :
    IGF-1R/InsR inhibitor,potent and selective
    BMS-754807 is a potent and small molecular inhibitor which targets the IGF-1R/IR family kinases with Ki <2 nmol/L. The efficacy of BMS-754807 on normal tissues and tumor cell cycle is believed to be different from the effects of continuous inhibition by anti-IGF-1R antibodies.
  8. AG-1024
    Catalog No. :
    Selective IGF-1R inhibitor
    AG1024 is an inhibitor of insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (IR) that specifically inhibits autophosphorylation of IGF-1R and IR with IC50 values of 7μM and 57 μm, respectively .
  9. BMS-536924
    Catalog No. :
    IR/IGF-1R inhibitor
    BMS-536924 is a novel inhibitor of IGF-1R with IC50 value of 100nM .
  10. AXL1717
    Catalog No. :
    IGF-1R inhibitor,orally active
    AXL1717 (Picropodophyllotoxin) is a selective inhibitor of IGF-1R with IC50 value rangs from 0.24-0.33 μM [1].

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