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NT157

Catalog No.
B7808
IRS-1/2 inhibitor, inhibits IGF-1R and STAT3 signaling pathway
Grouped product items
SizePriceStock Qty
2mg
$82.00
In stock
5mg
$152.00
In stock
25mg
$453.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

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Background

NT157 (CAS 1384426-12-3) is a small molecule inhibitor targeting insulin receptor substrates 1 and 2 (IRS-1/2), adaptor proteins involved in signaling cascades initiated by insulin, insulin-like growth factor-1 receptor (IGF-1R), and other oncogenic stimuli. NT157 exhibits inhibitory activity against IRS-1/2, reducing their expression in a dose-dependent manner (IC50: 0.3–0.8 μM), suppressing IGF-1-induced AKT phosphorylation, and augmenting ERK activation. In vitro studies demonstrate antiproliferative, pro-apoptotic effects and reduced cell migration. In vivo research supports NT157’s utility in inhibiting prostate cancer tumor growth, presenting it as a valuable research tool in oncology and signal transduction studies.

Product Citation

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt412.26
Cas No.1384426-12-3
FormulaC16H14BrNO5S
Solubilityinsoluble in H2O; ≥21.5 mg/mL in EtOH; ≥50 mg/mL in DMSO
Chemical Name(E)-3-(3-bromo-4,5-dihydroxyphenyl)-N-(3,4,5-trihydroxybenzyl)prop-2-enethioamide
SDFDownload SDF
Canonical SMILESOC1=C(O)C=C(/C=C/C(NCC2=CC(O)=C(O)C(O)=C2)=S)C=C1Br
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

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