Wee1 is a tyrosine kinase nuclear protein that catalyzes tyrosine phosphorylation of CDC2/Cyclin B kinase. It negatively regulates the entry to mitosis by protecting nucleus from cytoplasmically activated CDC2 kinase.
- MK-1775Catalog No. :A5755Wee1 kinase inhibtor,potent and ATP-competitive
MK-1775 is a potent and selective Wee1 kinase inhibitor with an IC50 of 5.2 nM.