HDAC
Histone deacetylases (HDACs), known for their ability to target histones as well as more than 50 non-histone proteins, are classified into three major classes according to their homology to yeast proteins, including class I (HDAC1, HDAC2, HDAC3 and HDAC8), class II (HDAC4, HDAC5, HDAC7 and HDAC9) and class IV (HDAC11). HDAC inhibitors, a large group of compounds that is able to induce the accumulation of acetylated histones as well as non-histone proteins, are divided into several structural classes including hydroxamates, cyclic peptides, aliphatic acids and benzamides. HDAC inhibitors have been investigated for their efficacy as anticancer agents in the treatment of a wild range of cancers.
- A4493 KD 51701 CitationSummary: HDAC inhibitor
- A4495 NCH 51Summary: Histone deacetylase (HDAC) inhibitor
- A4496 NSC 3852Target: Histone Deacetylases (HDACs)Summary: HDAC inhibitor
- A4497 PyroxamideTarget: Histone Deacetylases (HDACs)Summary: HDAC1 inhibitor
- A4499 TC-H 106Summary: HDAC inhibitor
- A4501 Tubacin3 CitationTarget: Histone Deacetylases (HDACs)Summary: HDAC6 inhibitor,potent,selective,reversible,cell-permeable
- A4494 LMK 235Summary: HDAC4/HDAC5 inhibitor
- A4498 SBHA1 CitationTarget: Histone Deacetylases (HDACs)Summary: HDAC1/HDAC3 inhibitor,cell-permeable
- A8547 Tubastatin A HCl1 CitationTarget: Histone Deacetylases (HDACs)Summary: HDAC6 inhibitor,potent and selective
- A9906 HDAC Set ISummary: For inhibiting HDAC