HDAC
Histone deacetylases (HDACs), known for their ability to target histones as well as more than 50 non-histone proteins, are classified into three major classes according to their homology to yeast proteins, including class I (HDAC1, HDAC2, HDAC3 and HDAC8), class II (HDAC4, HDAC5, HDAC7 and HDAC9) and class IV (HDAC11). HDAC inhibitors, a large group of compounds that is able to induce the accumulation of acetylated histones as well as non-histone proteins, are divided into several structural classes including hydroxamates, cyclic peptides, aliphatic acids and benzamides. HDAC inhibitors have been investigated for their efficacy as anticancer agents in the treatment of a wild range of cancers.
- A4083 Rocilinostat (ACY-1215)1 CitationTarget: Histone Deacetylases (HDACs)Summary: Selective HDAC6 inhibitor
- A4084 Vorinostat (SAHA, MK0683)9 CitationTarget: Histone Deacetylases (HDACs)Summary: HDAC inhibitor
- A4089 Mocetinostat (MGCD0103, MG0103)2 CitationTarget: Histone Deacetylases (HDACs)Summary: HDAC inhibitor,isotype-selective and potent
- A4090 JNJ-264815853 CitationTarget: Histone Deacetylases (HDACs)Summary: Potent HDAC inhibitor
- A4091 PCI-340511 CitationTarget: Histone Deacetylases (HDACs)Summary: HDAC8 inhibitor,potent and selective
- A4092 CUDC-1011 CitationTarget: Histone Deacetylases (HDACs)|EGFR|ErbBSummary: Multitargeted HDAC inhibitor
- A4093 ITF2357 (Givinostat)2 CitationTarget: Histone Deacetylases (HDACs)Summary: HDAC inhibitor
- A4106 Scriptaid1 CitationTarget: Histone Deacetylases (HDACs)Summary: HDAC inhibitor,novel and cell-permeable
- A4107 Sodium PhenylbutyrateTarget: Histone Deacetylases (HDACs)Summary: Histone deacetylase inhibitor
- A4108 Resminostat (RAS2410)1 CitationSummary: Potent HDAC inhibitor