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Chidamide

Catalog No.
B5916
Novel HDAC inhibitor
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$170.00
In stock
2mg
$80.00
In stock
5mg
$140.00
In stock
10mg
$240.00
In stock
50mg
$960.00
In stock

Tel: +1-832-696-8203

Email: [email protected]

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Background

Chidamide is a novel benzamide-type histone deacetylase (HDAC) inhibitor. People have investigated the effects of CS055 on proliferation, differentiation and apoptosis in human leukaemia cell lines and primary myeloid leukaemia cells.[1]

Histone deacetylases (HDACs) is a series of enzymes functioning to acetylate and deacetylate the amino-terminal lysine residues of histones, which result in the remodeling of the chromatin structures and affect the accessibility of the chromatin to transcription factors to start gene transcription.[2]

Chidamide has effect on cell cycle, it significantly reduced the S phase cell fraction, while inducing a marked increase in the G1 phase cell fraction in BEL-7402 and HCC-9204 cells with different p53 statuses. Chidamide signifiantly altered the number of cells in the phase fractions with an increase in dose.[2]

The results of the present study suggest that Chidamide is a HDACi with potential therapeutic value in several haematological malignancies via the inhibition of cell proliferation, inducing differentiation and apoptosis in human cells. Chidamide is a new HDACi with potential therapeutic values in several haematological malignancies via the inhibition of cell proliferation, inducing differentiation and apoptosis in human leukaemia cells.[1]

References:
[1] Gong K, Xie J, Yi H, Li W.  CS055 (Chidamide/HBI-8000), a novel histone deacetylase inhibitor, induces G1 arrest, ROS-dependent apoptosisand differentiation in human leukaemia cells. Biochem J. 2012 May 1;443(3):735-46.
[2] Wang H1, Guo Y, Fu M, Liang X, etal.  , Antitumor activity of Chidamide in hepatocellular carcinoma cell lines. Mol Med Rep. 2012 Jun;5(6):1503-8.

Product Citation

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt390.41
Cas No.743420-02-2
FormulaC22H19FN4O2
Solubilityinsoluble in H2O; insoluble in EtOH; ≥18.55 mg/mL in DMSO
Chemical Name(1Z,2E)-N-(4-((2-amino-5-fluorophenyl)carbamoyl)benzyl)-3-(pyridin-3-yl)acrylimidic acid
SDFDownload SDF
Canonical SMILESFC1=CC(NC(C2=CC=C(C/N=C(O)/C([H])=C([H])/C3=CN=CC=C3)C=C2)=O)=C(N)C=C1
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

Quality Control

Chemical structure

Chidamide

Related Biological Data

Chidamide