Chidamide
Catalog No.
B5916
Novel HDAC inhibitor
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Chidamide (CAS 743420-02-2) is a benzamide-based histone deacetylase (HDAC) inhibitor that targets enzymes responsible for the reversible acetylation of lysine residues on histone tails. By modulating HDAC activity, Chidamide promotes chromatin remodeling, influencing transcription factor access and subsequent gene transcription. In vitro studies on human leukemia cell lines and primary myeloid leukemia cells indicate that Chidamide induces cell cycle arrest at the G1 phase, differentiation, and apoptosis via ROS-dependent mechanisms. Therefore, Chidamide shows considerable potential in research focused on hematologic malignancies and cancer therapy.
- 1. Yi Que , Xiao-Long Zhang, et al. "Frequent amplification of HDAC genes and efficacy of HDAC inhibitor chidamide and PD-1 blockade combination in soft tissue sarcoma." J Immunother Cancer. 2021 Feb;9(2):e001696. PMID:33637599
- 2. Li Z, Luo J. "Research on epigenetic mechanism of SFRP2 in advanced chronic myeloid leukemia." Biochem Biophys Res Commun. 2018 Jun 18;501(1):64-72. PMID:29704505
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 390.41 |
| Cas No. | 743420-02-2 |
| Formula | C22H19FN4O2 |
| Solubility | insoluble in H2O; insoluble in EtOH; ≥18.55 mg/mL in DMSO |
| Chemical Name | N-(2-amino-5-fluorophenyl)-4-((3-(pyridin-3-yl)acrylamido)methyl)benzamide |
| SDF | Download SDF |
| Canonical SMILES | FC1=CC(NC(C2=CC=C(CNC(C=CC3=CC=CN=C3)=O)C=C2)=O)=C(N)C=C1 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
Related Biological Data
Related Biological Data
