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Cell Cycle/Checkpoint

The cell cycle is a regulatory system that controls the proper order and timing of cellular growth and division events. Mutation in the proteins regulating the cell cycle, leads to uncontrolled cell division or propagation of damaged DNA which contributes to genomic instability and oncogenesis.

The cell cycle is consisted of 4 main phases: Gap 1 (G1), DNA replication (S), Gap 2 (G2), and mitosis (M). There are “checkpoints” mechanism regulates the transition between these phases, at the G1/S boundary, in the S-phase and during G2/M phases. Cell can only pass through these checkpoints when signaling factors are activated and free of DNA damage. Important proteins that control cell cycle events and checkpoints are cullins, cyclins, cyclin-dependent kinases (Cdks), p53 and their inhibitors etc. Cdks family (Cdk2, Cdk3, Cdk4 and Cdk6) are Ser/Thr kinases that regulate cell cycle progression in association with cyclin binding partners (cyclin D, cyclin E and cyclin A) during all four phases. p53 halts the cell cycle if the DNA is damaged and allowing time for DNA repair to progress; it can also initiate apoptosis if DNA damage is too severe to be repaired.

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  1. THZ2
    Catalog No. :
    A8717
    CDK7 inhibitor

    THZ2 is a potent and selective CDK7 inhibitor (IC50=13.9 nM).

  2. SF1670
    Catalog No. :
    B4787
    PTEN inhibitor, potent and specific
    SF1670 is a potent and specific inhibitor of PTEN [1].
  3. Vinorelbine ditartrate
    Catalog No. :
    A3921
    Anti-mitotic chemotherapy drug

    Vinorelbine ditartrate

  4. CCT241533
    Catalog No. :
    A3291
    Potent Chk2 inhibitor
    CCT241533 is a selective inhibitor of CHK1 and CHK2 with IC50 value of 245 nM and 3 nM, respectively [1] [2].
  5. LY2606368 HCl
    Catalog No. :
    B8313
    CHK1 inhibitor

    LY2606368 HCl is a selective ATP competitive inhibitor of checkpoint kinase 1(CHK1) with IC50 value of 1.5nM in SW1990 cells .

  6. (S)-CCG-1423
    Catalog No. :
    C5803
    Rho inhibitor
  7. (R)-CCG-1423
    Catalog No. :
    C5799
    Rho inhibitor
  8. 10074-G5
    Catalog No. :
    C5722
    c-Myc inhibitor
  9. CFI-400945
    Catalog No. :
    C5813
    orally available, selective inhibitor of polo-like kinase 4 (PLK4)
  10. Eg5-I
    Catalog No. :
    C5188
    potent inhibitor of Eg5

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