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Gap Junction

Gap junctions are bunch of intercellular channels that allows transfer of ions and small through neighbouring cells. It is involved in regeneration, development and homeostasis regulation.

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  1. Gap 27
    Catalog No. :
    Selective gap junction blocker

    Gap 27 is a peptide(Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile) derived from connexin 43 that is a selective gap junction blocker.

  2. Gap 26
    Catalog No. :
    Gap junction blocker peptide, mapping to connexin 43 residue 63-75

    Gap26 (Val-Cys-Tyr-Asp-Lys-Ser-Phe-Pro-Ile-Ser-His-Val-Arg) is a connexin mimetic peptide, corresponding to residues 63-75 of connexin 43, which is a gap junction blocker.

  3. Gap19
    Catalog No. :
    Selective connexin 43 (Cx43) hemichannel blocker
  4. Carbenoxolone disodium
    Catalog No. :
    11β-HSD inhibitor

    Carbenoxolone disodium is an inhibitor of 11β-hydroxysteroid dehydrogenase (11β-HSD) [1].

  5. Scrambled 10Panx
    Catalog No. :
    Panx-1 mimetic inhibitory peptide, blocks pannexin-1 gap junctions
    Scrambled 10Panx is the scrambled form of 10Panx (WRQAAFVDSY), a mimetic peptide of pannexin 1 that inhibits dye uptake by macrophages without affecting cellular membrane currents.
  6. 10Panx
    Catalog No. :
    Panx-1 mimetic inhibitor
    10Panx is a mimetic inhibitory peptide of panx1, which is a mammalian protein ectopically expressed to function as a hemi-channel, that readily and reversibly inhibits the panx1 currents.
  7. Semagacestat (LY450139)
    Catalog No. :
    γ-secretase inhibitor
    Semagacestat (also known as LY450139), [(2S)-2-hydroxy-N-((2S)-1-((1S)-3-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1ylamino)-1-oxopropan-2-yl)-3-methylbutanamide] is an azepine class γ-secretase, which is currently being investigated as a potential disease-modifying agent for the treatment of Alzheimer’s disease (AD).

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