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Hedgehog

Hh (Hedgehog) signalling is a evolutionarily conserved pathway that is critical for embryonic development, tissue and organ morphogenesis. Mammalian Hh protein ligands include Sonic Hh, Desert Hh and Indian Hh. Dysfunctions of Hh singalling lead to developmental abnormalities and cancer.

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  1. GDC-0449 (Vismodegib)
    A3021 GDC-0449 (Vismodegib)
     1 Citation
    Target: P-glycoprotein (P-gp)|Hedgehog
    Summary: Hedgehog antagonist,potent and selective
      ≥21.08 mg/mL
  2. GANT 58
    A3429 GANT 58
    Summary: GLI antagonist,novel and potent
  3. MK-4101
    B7803 MK-4101
    Summary: Hedgehog (Hh) signaling pathway inhibitor
      Soluble in DMSO
  4. Oxy-16
    C5136 Oxy-16
    Summary: antagonist of hedgehog activity
      ≤10 mg/mL
  5. CUR 61414
    C5138 CUR 61414
    Summary: potent inhibitor of hedgehog-induced cellular activity
      ≤10 mg/mL
  6. U 18666A
    B6812 U 18666A
    Summary: inhibitor of cholesterol transport and synthesis
      Soluble in H2O
  7. 20(S)-Hydroxycholesterol
    B7669 20(S)-Hydroxycholesterol
    Summary: Allosteric activator of the Hedgehog signaling pathway Smoothened (Smo) oncoprotein
      Soluble in ethanol
  8. SAG
    B5837 SAG
    Summary: Hh and Smo agonist
      ≥24.5 mg/mL
  9. Purmorphamine
    A8228 Purmorphamine
    Summary: Hedgehog agonist
  10. GANT61
    A1615 GANT61
     1 Citation
    Target: GLI
    Summary: GLI antagonist

Items 1-10 of 21

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