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Hedgehog

Hh (Hedgehog) signalling is a evolutionarily conserved pathway that is critical for embryonic development, tissue and organ morphogenesis. Mammalian Hh protein ligands include Sonic Hh, Desert Hh and Indian Hh. Dysfunctions of Hh singalling lead to developmental abnormalities and cancer.

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  1. GDC-0449 (Vismodegib)
    A3021 GDC-0449 (Vismodegib)
     1 Citation
    Target: P-glycoprotein (P-gp)|Hedgehog
    Summary: Hedgehog antagonist,potent and selective
      ≥21.08 mg/mL
  2. GANT 58
    A3429 GANT 58
    Summary: GLI antagonist,novel and potent
  3. Purmorphamine
    A8228 Purmorphamine
    Summary: Hedgehog agonist
  4. GANT61
    A1615 GANT61
     1 Citation
    Target: GLI
    Summary: GLI antagonist
  5. Cyclopamine
    A8340 Cyclopamine
     1 Citation
    Target: Smoothened
    Summary: Hedgehog (Hh) signaling Inhibitor
      insoluble in EtOH; insoluble in H2O; ≥6.86 mg/mL
  6. PF-5274857
    A8500 PF-5274857
    Summary: Smo antagonist,potent and selective
      insoluble in EtOH; ≥17.6 mg/mL
  7. CHIR-99021 (CT99021) HCl
    A8396 CHIR-99021 (CT99021) HCl
    Target: GSK-3
    Summary: GSK-3α/β inhibitor
      ≥25.1 mg/mL
  8. LY2940680
    A8651 LY2940680
    Target: Smoothened receptor
    Summary: Hedgehog/SMO antagonist,inhibits Hh signaling
  9. JK 184
    A8652 JK 184
    Summary: Hh signaling inhibitor
      Soluble in DMSO
  10. SANT-2
    A8653 SANT-2
    Summary: Hedgehog signaling inhibitor
      Soluble in DMSO

Items 1-10 of 21

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