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JAK/STAT Signaling

The JAK (Janus kinase) / STAT (signal transducer and activator of transcription) signaling pathway transduce signals that are essential for development, cellular differentiation and homeostasis. This pathway plays a critical role in cytokine receptor systems, regulating growth, survival and pathogen resistance. JAK is a family of non-receptor protein tyrosine kinases, consisting of JAK1, JAK2, JAK3 and TYK2 (Tyrosine Kinase-2). STATs are transcription factors that activated following recruitment to an activated receptor complex, seven STAT proteins have been identified: STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B and STAT6.

Various ligands including cytokines (e.g. interferons and interleukins), hormones (e.g. erythropoietin and growth hormone) and their cell surface receptors activate JAK proteins, which autophosphorylate, and then phosphorylate the receptor. Subsequently, JAKs phosphorylate a specific tyrosine residue on the STAT protein, promoting dimerization via SH2 domains. The activated STATs form homo-/heterodimers and translocate to the nucleus to trigger target gene transcription. In addition, suppressors of cytokine signaling (SOCS) family inhibit receptor signaling via homologous or heterologous feedback regulation. Dysregulation in JAK/STAT signaling is associated with diseases such as atherosclerosis, immunodeficiencies and cancer.

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  1. Galiellalactone
    Catalog No. :
    C4650
    inhibits IL-6-mediated JAK/STAT signal transduction
  2. RO8191
    Catalog No. :
    C4533
    IFN-α receptor 2 agonist
  3. STAT5 Inhibitor
    Catalog No. :
    C4105
    STAT5 inhibitor
  4. 5,15-DPP
    Catalog No. :
    C3975
    STAT3 inhibitor
  5. APTSTAT3-9R
    Catalog No. :
    B7802
    STAT3 inhibitor
  6. STA-21
    Catalog No. :
    B6175
    STAT3 inhibitor
  7. RG 13022
    Catalog No. :
    B6115
    EGFR tyrosine kinase inhibitor
  8. FLLL32
    Catalog No. :
    B5999
    STAT3 inhibitor
  9. AZD3759
    Catalog No. :
    B5962
    EGFR inhibitor,oral active
    AZD3759 is a potent and oral active inhibitor of EGFR (IC50= 7.0-7.7 nM) with antineoplastic activity
  10. AZ5104
    Catalog No. :
    B5836
    EGFR inhibitor
    AZ5104, is the demethylated metabolite of AZD-9291,is a potent EGFR inhibitor. IC50 <1 nM, 6 nM, 1 nM, 25 nM, for EGFR (L858R/T790M), EGFR (L858R), EGFR (L861Q), and EGFR (wildtype), respectively.

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