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LestaurtinibJAK2/FLT3/TrkA inhibitor

Lestaurtinib

Catalog No. A4513
Size Price Stock Qty
1mg $303.00 In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical structure

Lestaurtinib

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Chemical Properties

Cas No. 111358-88-4 SDF Download SDF
Chemical Name (5S,6S,8R)-6-hydroxy-6-(hydroxymethyl)-5-methyl-7,8,14,15-tetrahydro-5H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacen-13(6H)-one
Canonical SMILES O=C(NC1)C2=C1C(C(C=CC=C3)=C3N45)=C4C(N6[C@@H]7O[C@@]5(C)[C@](CO)(O)C7)=C2C8=C6C=CC=C8
Formula C25H21N3O4 M.Wt 439.46
Solubility Soluble in DMSO > 10 mM Storage Desiccate at -20°C
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Background

Potent JAK2, FLT3 and TrkA inhibitor (IC50 values are 0.9, 3 and < 25 nM respectively) that prevents STAT5 phosphorylation (IC50 = 20 - 30 nM). Exhibits antiproliferative activity in vitro (IC50 = 30 - 100 nM in HEL92.1.7 cells) and is effective against myeloproliferative disorders in vivo.