1,2,3,4,5,6-Hexabromocyclohexane
Catalog No.
A4510
JAK2 tyrosine kinase inhibitor
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1,2,3,4,5,6-Hexabromocyclohexane (CAS 1837-91-8) is a small molecule inhibitor targeting Janus kinase 2 (JAK2). It directly suppresses JAK2 tyrosine kinase activity by blocking ligand-induced autophosphorylation. Experimental data indicate that treatment with 1 μM of the compound for 16 hours decreases JAK2 autophosphorylation by approximately 50%, whereas exposure to 50 μM essentially abolishes kinase activity. Notably, it does not exhibit cytotoxicity at concentrations up to 100 μM. This compound serves as a valuable research tool for studying JAK2 signaling pathways and related cellular processes.
| Physical Appearance | A solid |
| Storage | Store at RT |
| M.Wt | 557.54 |
| Cas No. | 1837-91-8 |
| Formula | C6H6Br6 |
| Solubility | insoluble in EtOH; insoluble in H2O; ≥8.22 mg/mL in DMSO with gentle warming |
| Chemical Name | 1,2,3,4,5,6-hexabromocyclohexane |
| SDF | Download SDF |
| Canonical SMILES | C1(C(C(C(C(C1Br)Br)Br)Br)Br)Br |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
