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1,2,3,4,5,6-Hexabromocyclohexane

Catalog No.
A4510
JAK2 tyrosine kinase inhibitor
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$121.00
In stock
50mg
$117.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

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Background

1,2,3,4,5,6-Hexabromocyclohexane (CAS 1837-91-8) is a small molecule inhibitor targeting Janus kinase 2 (JAK2). It directly suppresses JAK2 tyrosine kinase activity by blocking ligand-induced autophosphorylation. Experimental data indicate that treatment with 1 μM of the compound for 16 hours decreases JAK2 autophosphorylation by approximately 50%, whereas exposure to 50 μM essentially abolishes kinase activity. Notably, it does not exhibit cytotoxicity at concentrations up to 100 μM. This compound serves as a valuable research tool for studying JAK2 signaling pathways and related cellular processes.

Chemical Properties

Physical AppearanceA solid
StorageStore at RT
M.Wt557.54
Cas No.1837-91-8
FormulaC6H6Br6
Solubilityinsoluble in EtOH; insoluble in H2O; ≥8.22 mg/mL in DMSO with gentle warming
Chemical Name1,2,3,4,5,6-hexabromocyclohexane
SDFDownload SDF
Canonical SMILESC1(C(C(C(C(C1Br)Br)Br)Br)Br)Br
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Chemical structure

1,2,3,4,5,6-Hexabromocyclohexane