R8-T198wt
Catalog No.
A4520
Pim-1 kinase inhibitor
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Cell-permeable peptide inhibitor of Pim-1 kinase, derived from p27Kip1. Inhibits Pim-1 phosphorylation of p27Kip1 and Bad; induces cell cycle arrest (at G1) and apoptosis in DU145 prostate cancer cells. Also inhibits Pim-1-dependent growth of DU145 cells in vitro and in vivo. Displays no effect on the growth of normal prostate epithelial RPWE-1 cells at concentrations of 10 and 20 μM.
Physical Appearance | White lyophilised solid |
Storage | Store at -20°C |
M.Wt | 2820.31 |
Formula | C111H211N59O26S |
Solubility | Soluble to 2 mg/ml in 20% acetonitrile / H2O |
Chemical Name | (1Z,4Z,6S,7Z,9S,10Z,12S,13Z,15S,16Z,18S,19Z,21S)-1-((S)-1-((2S,3Z,5S,6Z,8R,9Z,12Z,14S,15Z,17S,18Z,20S,21Z,23S,24Z,26S,27Z,29S,30Z,32S,33Z,35S,36Z,39Z,42Z)-44-amino-2,5-bis(4-aminobutyl)-14,17,20,23,26,29,32,35-octakis(3-guanidinopropyl)-4,7,10,13,16,19,22 |
SDF | Download SDF |
Canonical SMILES | CC(C[C@@](/N=C(O)/C/N=C(O)/[C@]1([H])CCCN1C([C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/C/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/C/N=C(O)/C/N=C(O)/CN)([H])CCCNC(N)=N)([H])CCCNC(N)=N)([H])C |
Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
- Datasheet
Chemical structure
