Monoamine oxidases (MAOs) are a family of enzymes that oxidize a number of biogenic amines through the production of hydrogen peroxide (H2O2). Two members of the MAO family have been identified and designated, MAO A and MAO B, which are encoded by two homologous genes comprising 15 exons with identical intro-exon organization and exhibit substrate-specificity. MAO A displays higher affinity towards serotonin, norepinephrine and dopamine; while MAO B displays higher affinity towards phenylethylamine and benzylamine. Four highly conserved regions associated with the catalytic activity of mammalian MAO enzymes have been identified, including an ADP binding β-α-β unit, a putative substrate-binding domain, a FAD covalent attachment site, and a C terminus region predicted to form a transmembrane-associated α-helix.
- Clorgyline (hydrochloride)Catalog No. :C4137MAO-A inhibitor
- Pargyline (hydrochloride)Catalog No. :C3106MAO inhibitor
- IsatinCatalog No. :B6153endogenous monoamine oxidase inhibitor
- Moclobemide (Ro 111163)Catalog No. :A4370Reversible inhibitor of MAO-A
Moclobemide is a reversible inhibitor of monoamine oxidase-A (MAO-A) with IC50 value of 10μM .
- Safinamide MesylateCatalog No. :A4368MAO-B inhibitor,potent,selective and reversibleSafinamide mesylate is the methanesulfonic acid form of its active component safinamide, a selective and reversible monoamine oxidase B (MAO-B) inhibitor with the value of 50% inhibition concentration IC50 of 98 nM.
- Rasagiline MesylateCatalog No. :A4366Irreversible MAO-B inhibitorRasagiline mesylate is a new MAO-B inhibitor for the treatment of idiopathic Parkinson's disease.