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Monoamine oxidases (MAOs) are a family of enzymes that oxidize a number of biogenic amines through the production of hydrogen peroxide (H2O2). Two members of the MAO family have been identified and designated, MAO A and MAO B, which are encoded by two homologous genes comprising 15 exons with identical intro-exon organization and exhibit substrate-specificity. MAO A displays higher affinity towards serotonin, norepinephrine and dopamine; while MAO B displays higher affinity towards phenylethylamine and benzylamine.  Four highly conserved regions associated with the catalytic activity of mammalian MAO enzymes have been identified, including an ADP binding β-α-β unit, a putative substrate-binding domain, a FAD covalent attachment site, and a C terminus region predicted to form a transmembrane-associated α-helix.

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  1. Clorgyline (hydrochloride)
    Catalog No. :
    MAO-A inhibitor
  2. Pargyline (hydrochloride)
    Catalog No. :
    MAO inhibitor
  3. Isatin
    Catalog No. :
    endogenous monoamine oxidase inhibitor
  4. Moclobemide (Ro 111163)
    Catalog No. :
    Reversible inhibitor of MAO-A

    Moclobemide is a reversible inhibitor of monoamine oxidase-A (MAO-A) with IC50 value of 10μM .

  5. Safinamide Mesylate
    Catalog No. :
    MAO-B inhibitor,potent,selective and reversible
    Safinamide mesylate is the methanesulfonic acid form of its active component safinamide, a selective and reversible monoamine oxidase B (MAO-B) inhibitor with the value of 50% inhibition concentration IC50 of 98 nM.
  6. Rasagiline Mesylate
    Catalog No. :
    Irreversible MAO-B inhibitor
    Rasagiline mesylate is a new MAO-B inhibitor for the treatment of idiopathic Parkinson's disease.

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