Histone acetyltransferases (HATs) are a diverse group of enzymes catalyzing a posttranslational modification of acetylation in which the acetyl group from the acetyl-CoA cofactor is transferred to the Nζ nitrogen of the target lysine side chain within histones. Based on the sequence divergence within the HAT domain, HATs is classified into at least five distinct families, including HAT1 family, Gcn5/PCAF family, MYST family, p300/CBP family and Rtt109 family. Despite the sequence divergence, a structurally conserved core region has been identified within each of the protein families, which contains a three-stranded β-sheet with a α—helix corresponding to the A and D regions of the Gcn5-related N-acetyltransferases (GNAT) proteins.
- B7250 YM 750Summary: Acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor
- B7241 VULM 1457Summary: Acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor
- B6987 CI 976Summary: acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibitor
- B1577 C6461 CitationTarget: p300Summary: HAT p300-CBP inhibitor,cell-permeable
- B1602 Donepezil HClTarget: AChESummary: AChE inhibitor
- B3276 MG 1492 CitationSummary: HAT inhibitor
- A4492 NU 9056Target: Histone Acetyltransferases (HATs)Summary: KAT5 (Tip60) HAT inhibitor