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Troglitazone

Catalog No.
A3893
Selective PPARγ agonist
Grouped product items
SizePriceStock Qty
10mg
$81.00
In stock
50mg
$317.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

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Email: [email protected]

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Background

Troglitazone (CAS 97322-87-7) is a synthetic small molecule agonist of peroxisome proliferator-activated receptor gamma (PPARγ), and exhibits dual activity towards PPARγ/α. Primarily developed as a therapeutic agent for type 2 diabetes, it modulates lipid and glucose metabolism by activating nuclear receptor pathways. In vitro, troglitazone reduces proliferation and induces apoptosis in human renal carcinoma cells, suggesting potential anti-tumor functionality. In animal models, prolonged administration at high doses (400-800 mg/kg) promotes endothelial cell proliferation. Clinically, troglitazone has been investigated for safety and pharmacokinetics in patients with diabetes and liposarcoma.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt441.54
Cas No.97322-87-7
FormulaC24H27NO5S
SynonymsRezulin;CS-045;Noscal
Solubilityinsoluble in H2O; ≥20.9 mg/mL in DMSO; ≥3.34 mg/mL in EtOH with gentle warming and ultrasonic
Chemical Name5-[[4-[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromen-2-yl)methoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
SDFDownload SDF
Canonical SMILESCC1=C(C(=C2CCC(OC2=C1C)(C)COC3=CC=C(C=C3)CC4C(=O)NC(=O)S4)C)O
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Biological Activity

Description Troglitazone(CS-045) is a agonist of PPARγ.
Targets PPARγ          
IC50            

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