Rosiglitazone maleate
Catalog No.
A4302
PPARγ agonist,high-affinity and selective,potent insulin sensitizer
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Rosiglitazone maleate (CAS 155141-29-0) is the maleate salt formulation of rosiglitazone, a thiazolidinedione compound targeting the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ). By selective activation of PPARγ, rosiglitazone increases insulin sensitivity of peripheral tissues, facilitating glucose uptake and reduction of blood glucose levels. Due to its insulin-sensitizing activity, rosiglitazone maleate serves as an important research tool in diabetes and metabolic syndrome investigations. However, recent clinical studies also report associations with adverse cardiovascular events, fluid retention, and anemia, underscoring considerations for risk-benefit evaluation in ongoing research.
| Storage | Store at -20°C |
| M.Wt | 473.5 |
| Cas No. | 155141-29-0 |
| Formula | C18H19N3O3S·C4H4O4 |
| Synonyms | Avandia,Avandaryl,BRL 49653C,BRL-49653C |
| Solubility | ≥23.7 mg/mL in DMSO; insoluble in H2O; ≥19 mg/mL in EtOH with ultrasonic |
| Chemical Name | (Z)-but-2-enedioic acid;5-[[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione |
| SDF | Download SDF |
| Canonical SMILES | CN(CCOC1=CC=C(C=C1)CC2C(=O)NC(=O)S2)C3=CC=CC=N3.C(=CC(=O)O)C(=O)O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
