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Nordihydroguaiaretic acid

Catalog No.
A3664
Anti-tumor agent;lipoxygenase inhibitor
Grouped product items
SizePriceStock Qty
100mg
$50.00
In stock
500mg
$150.00
Ship with 10-15 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Description: IC50 Value: N/A Nordihydroguaiaretic acid (NDGA) is a natural phenolic compound isolated from the creosote bush Larrea divaricata, which has anti-tumor activities both in vitro and in vivo. Its analogs are in clinical development for use in refractory solid tumors. in vitro: NDGA may also direct target mTORC1 complex because NDGA suppressed amino acids- and insulin-stimulated mTORC1 and acted like rapamycin to disrupt mTOR-Raptor interaction [1]. NDGA increased PPARα promoter activity in AML12 hepatocytes and also prevented the fatty acid suppression of PPARα expression. In contrast, PPARα siRNA abrogated the stimulatory effect of NDGA on fatty acidcatabolism [2]. in vivo: NDGA was able to induce Nrf2 translocation in vivo in kidneys of rats submitted to both U-NX and I/R injury and to protect against renal histological damage and apoptosis [3]. Comparison of the proportion of live mice at the age of 90% mortality was used as a surrogate for measurement of maximum lifespan;neither NDGA (p=0.12) nor aspirin (p=0.16) had a significant effect in this test. Measures of blood levels of NDGA or aspirin and its salicylicacid metabolite suggest that the observed lack of effects of NDGA or aspirin on life span in females could be related to gender differences in drug disposition or metabolism [4]. Clinical trial: Nordihydroguaiaretic Acid in Treating Patients With Nonmetastatic Relapsed Prostate Cancer . Phase 1

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt302.36
Cas No.500-38-9
FormulaC18H22O4
SynonymsNDGA
Solubilityinsoluble in H2O; ≥107 mg/mL in EtOH; ≥121 mg/mL in DMSO
Chemical Name4,4'-(2,3-dimethylbutane-1,4-diyl)bis(benzene-1,2-diol)
SDFDownload SDF
Canonical SMILESCC(C(CC1=CC(O)=C(O)C=C1)C)CC2=CC(O)=C(O)C=C2
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control