Dimethyl Fumarate
Catalog No.
B1931
nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator
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Dimethyl fumarate (CAS: 624-49-7) is a small-molecule activator targeting the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway. It promotes Nrf2 nuclear translocation, inducing transcription of antioxidant response genes, thereby modulating oxidative stress response pathways.
In cell-based assays, dimethyl fumarate activates Nrf2 with an IC50 value of approximately 5 μM.
Dimethyl fumarate is utilized in studies of oxidative stress, inflammation, and related pathophysiological processes.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 144.13 |
| Cas No. | 624-49-7 |
| Formula | C6H8O4 |
| Solubility | insoluble in H2O; ≥6.7 mg/mL in EtOH with gentle warming and ultrasonic; ≥7.1 mg/mL in DMSO |
| Chemical Name | dimethyl (E)-but-2-enedioate |
| SDF | Download SDF |
| Canonical SMILES | COC(C=CC(OC)=O)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
