Oltipraz
Oltipraz (CAS: 64224-21-1) is a small-molecule activator targeting the nuclear factor erythroid 2–related factor 2 (Nrf2) signaling pathway. It is designed to induce phase II detoxifying enzymes, thereby modulating cellular defense mechanisms against xenobiotic and carcinogen exposure.
Oltipraz exerts its biological activity primarily through upregulation of phase II enzymes, including glutathione S-transferase (GST) and NAD(P)H:quinone oxidoreductase (NQO1). In rat hepatocyte assays, Oltipraz demonstrates enzyme induction activity, with an IC50 of approximately 10–30 μM.
Oltipraz holds research potential in chemoprevention and protection against carcinogen-related toxicity by modulation of Nrf2 signaling pathways.
Reference:
[1] Clapper ML. Chemopreventive activity of oltipraz. Pharmacol Ther. 1998 Apr;78(1):17-27.
[2] Benson AB 3rd. Oltipraz: a laboratory and clinical review. J Cell Biochem Suppl. 1993;17F:278-91.
- 1. Yi-Yang Liu, Hong Qin, et al. "Qushi Huoxue ointment ameliorates metabolic associated steatotic liver disease through autophagy activation and ferroptosis inhibition." World J Hepatol. 2026 Feb 27;18(2):115763. PMID: 41809478
- 2. Xize Wu, Xue Pan, et al. "Ferulic acid inhibits ox-LDL-induced ferroptosis and apoptosis in RAW 264.7 cells via the HIF-1 signaling pathway." Front Pharmacol. 2025 Mar 18:16:1524736. PMID: 40170728
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 226.34 |
| Cas No. | 64224-21-1 |
| Formula | C8H6N2S3 |
| Solubility | ≥22.6 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH |
| Chemical Name | 4-methyl-5-(pyrazin-2-yl)-3H-1,2-dithiole-3-thione |
| Canonical SMILES | CC1=C(c2nccnc2)SSC1=S |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
