Oltipraz
Oltipraz (CAS: 64224-21-1) is a small-molecule activator targeting the nuclear factor erythroid 2–related factor 2 (Nrf2) signaling pathway. It is designed to induce phase II detoxifying enzymes, thereby modulating cellular defense mechanisms against xenobiotic and carcinogen exposure.
Oltipraz exerts its biological activity primarily through upregulation of phase II enzymes, including glutathione S-transferase (GST) and NAD(P)H:quinone oxidoreductase (NQO1). In rat hepatocyte assays, Oltipraz demonstrates enzyme induction activity, with an IC50 of approximately 10–30 μM.
Oltipraz holds research potential in chemoprevention and protection against carcinogen-related toxicity by modulation of Nrf2 signaling pathways.
Reference:
[1] Clapper ML. Chemopreventive activity of oltipraz. Pharmacol Ther. 1998 Apr;78(1):17-27.
[2] Benson AB 3rd. Oltipraz: a laboratory and clinical review. J Cell Biochem Suppl. 1993;17F:278-91.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 226.34 |
| Cas No. | 64224-21-1 |
| Formula | C8H6N2S3 |
| Solubility | ≥22.6 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH |
| Chemical Name | 4-methyl-5-(pyrazin-2-yl)-3H-1,2-dithiole-3-thione |
| SDF | Download SDF |
| Canonical SMILES | CC1=C(c2nccnc2)SSC1=S |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
