CDDO-TFEA
Catalog No.
C4354
Nrf2 activator
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CDDO-TFEA (CAS 932730-52-4) is a synthetic triterpenoid derivative functioning as an activator of the Nrf2/ARE signaling pathway. Activation of this pathway induces nuclear translocation of Nrf2 and enhances the expression of downstream antioxidant enzymes such as NQO-1, HO-1, and glutathione reductase. In experimental models, CDDO-TFEA decreased inflammatory cell infiltration and cytokine production (IL-6, IL-17, IFNγ, TNFα, GMCSF), reduced neuroinflammation, and promoted neuronal survival. Its modulatory effects position CDDO-TFEA as relevant for research involving neurodegenerative conditions including ALS and Huntington’s disease.
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 572.7 |
| Cas No. | 932730-52-4 |
| Formula | C33H43F3N2O3 |
| Synonyms | CDDO-Trifluoethyl Amide,RTA 404,TP-500 |
| Solubility | ≤5mg/ml in ethanol;5mg/ml in DMSO;5mg/ml in dimethyl formamide |
| Chemical Name | 2-cyano-3,12-dioxo-N-(2,2,2-trifluoroethyl)-oleana-1,9(11)-dien-28-amide |
| SDF | Download SDF |
| Canonical SMILES | CC1(CC[C@@]2(CC[C@@](C)([C@@]3(CC[C@]4(C(C)(C(C(C#N)=C[C@@]4(C3=CC5=O)C)=O)C)[H])C)[C@]5([C@@]2(C1)[H])[H])C(NCC(F)(F)F)=O)C |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
- View current batch:
-
Purity ≥ 95.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
