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CDDO-TFEA

Catalog No.
C4354
Nrf2 activator
Grouped product items
SizePriceStock Qty
1mg
$91.00
Ship with 5-10 days
5mg
$409.00
Ship with 5-10 days
10mg
$724.00
Ship with 5-10 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

CDDO-TFEA (CAS 932730-52-4) is a synthetic triterpenoid derivative functioning as an activator of the Nrf2/ARE signaling pathway. Activation of this pathway induces nuclear translocation of Nrf2 and enhances the expression of downstream antioxidant enzymes such as NQO-1, HO-1, and glutathione reductase. In experimental models, CDDO-TFEA decreased inflammatory cell infiltration and cytokine production (IL-6, IL-17, IFNγ, TNFα, GMCSF), reduced neuroinflammation, and promoted neuronal survival. Its modulatory effects position CDDO-TFEA as relevant for research involving neurodegenerative conditions including ALS and Huntington’s disease.

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt572.7
Cas No.932730-52-4
FormulaC33H43F3N2O3
SynonymsCDDO-Trifluoethyl Amide,RTA 404,TP-500
Solubility≤5mg/ml in ethanol;5mg/ml in DMSO;5mg/ml in dimethyl formamide
Chemical Name2-cyano-3,12-dioxo-N-(2,2,2-trifluoroethyl)-oleana-1,9(11)-dien-28-amide
SDFDownload SDF
Canonical SMILESCC1(CC[C@@]2(CC[C@@](C)([C@@]3(CC[C@]4(C(C)(C(C(C#N)=C[C@@]4(C3=CC5=O)C)=O)C)[H])C)[C@]5([C@@]2(C1)[H])[H])C(NCC(F)(F)F)=O)C
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

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Chemical structure

CDDO-TFEA