Flumazenil
Flumazenil is a small-molecule competitive antagonist at the benzodiazepine binding site of the GABA-A receptor. It rapidly reverses the central depressant effects of benzodiazepines, including sedation, impaired cognition, and hypoventilation. As a high-affinity, small-molecule inhibitor, it serves as an essential pharmacological tool in neuroscience research.
Its primary research application is the specific blockade or reversal of effects mediated by benzodiazepine site agonists and positive allosteric modulators. It is invaluable for validating the mechanism of action, defining receptor occupancy, and studying GABAergic neurotransmission in vitro and in vivo. This compound is fundamental for investigating receptor subunit composition, allosteric modulation, and in behavioral studies of anxiety, memory, and sedation.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 303.29 |
| Cas No. | 78755-81-4 |
| Formula | C15H14FN3O3 |
| Solubility | insoluble in H2O; insoluble in EtOH; ≥30.38 mg/mL in DMSO |
| Chemical Name | ethyl 8-fluoro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate |
| SDF | Download SDF |
| Canonical SMILES | CCOC(c(nc1)c(CN2C)[n]1-c(ccc(F)c1)c1C2=O)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
- View current batch:
Chemical structure
Related Biological Data
