Acamprosate calcium
mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Inhibitor Cocktails
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Acamprosate calcium is a synthetic drug for abstinence of patients with alcohol dependence [1].
Acamprosate administration can reduce alcohol intake. In rat model, oral acamprosate at dose of 50 to 400 mg/kg/day reduced voluntary oral ethanol consumption dose-dependently. However, the exact cellular target and mechanism of acamprosate is not clear. Acamprosate has a structure similar to that of GABA. It can specifically bind to GABAB receptors but not GABAA receptors. Besides that, acamprosate showed serotonergic properties. It increased 5-HT levels and the effects caused by 5-HT in rats exposed to ethanolvapour. Moreover, acamprosate was thought to have effects on inhibiting the excitatory activity of aminoacid and reducing Ca2+fluxes [1].
References:
1. Wilde M I, Wagstaff A J. Acamprosate. Drugs, 1997, 53(6): 1038-1053.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 400.48 |
| Cas No. | 77337-73-6 |
| Formula | C10H20CaN2O8S2 |
| Synonyms | Calcium N-acetylhomotaurinate; Campral EC |
| Solubility | ≥40 mg/mL in H2O; insoluble in DMSO; insoluble in EtOH |
| Chemical Name | calcium;3-acetamidopropane-1-sulfonate |
| SDF | Download SDF |
| Canonical SMILES | CC(=O)NCCCS(=O)(=O)[O-].CC(=O)NCCCS(=O)(=O)[O-].[Ca+2] |
| Shipping Condition | Evaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request. |
| General tips | For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months. |
Quality Control & MSDS
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Chemical structure
