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Acamprosate calcium

Catalog No.
A3142
GABA receptor agonist and modulator of glutamatergic systems
Grouped product items
SizePriceStock Qty
50mg
$51.00
In stock

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Background

Acamprosate calcium is a synthetic drug for abstinence of patients with alcohol dependence [1].

Acamprosate administration can reduce alcohol intake. In rat model, oral acamprosate at dose of 50 to 400 mg/kg/day reduced voluntary oral ethanol consumption dose-dependently. However, the exact cellular target and mechanism of acamprosate is not clear. Acamprosate has a structure similar to that of GABA. It can specifically bind to GABAB receptors but not GABAA receptors. Besides that, acamprosate showed serotonergic properties. It increased 5-HT levels and the effects caused by 5-HT in rats exposed to ethanolvapour. Moreover, acamprosate was thought to have effects on inhibiting the excitatory activity of aminoacid and reducing Ca2+fluxes [1].

References:
1. Wilde M I, Wagstaff A J. Acamprosate. Drugs, 1997, 53(6): 1038-1053.

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt400.48
Cas No.77337-73-6
FormulaC10H20CaN2O8S2
SynonymsCalcium N-acetylhomotaurinate; Campral EC
Solubility≥40 mg/mL in H2O; insoluble in DMSO; insoluble in EtOH
Chemical Namecalcium;3-acetamidopropane-1-sulfonate
SDFDownload SDF
Canonical SMILESCC(=O)NCCCS(=O)(=O)[O-].CC(=O)NCCCS(=O)(=O)[O-].[Ca+2]
Shipping ConditionEvaluation sample solution: ship with blue ice. All other available sizes: ship with RT, or blue ice upon request.
General tipsFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.

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