SR 95531 hydrobromide

SR 95531 Hydrobromide (CAS 104104-50-9) is a highly potent and selective competitive antagonist belonging to the GABA_A receptor antagonist class, functioning as a blocker of GABA-mediated neurotransmission in neuronal tissue and exhibiting inhibitory activity on GABA_A receptor-mediated signals in central nervous system preparations. Additionally, it prevents GABA binding to its ionotropic receptor, thereby inhibiting the associated chloride ion flux.

In various in vitro experimental models, SR 95531 Hydrobromide suppresses GABA-induced currents with an IC50 of approximately 0.2 μM, tested against primary neuronal cultures and recombinant cell lines expressing GABA_A receptors. It can also inhibit spontaneous inhibitory postsynaptic currents and modulate synaptic inhibition at the cellular level, providing a valuable tool for dissecting inhibitory neurotransmission mechanisms.

In pharmacological and neurophysiological research applications, SR 95531 Hydrobromide is widely used for investigating GABAergic system function as well as for characterizing the involvement of GABA_A receptors in neural circuitry, synaptic plasticity, and seizure models. This compound aids in elucidating the physiological roles of inhibitory neurotransmission and is frequently employed in studies assessing the effects of GABA_A receptor antagonism in animal models and isolated tissue preparations.