WIKI4
Catalog No.
A4531
Inhibitor of Wnt/ß-Catenin signaling and tankyrase
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Inhibitor of Wnt/β-catenin signaling (EC50 ~ 75 nM). Inhibits auto-ADP-ribosylation of tankyrase 2 (TNKS2) (IC50 ~15 nM); prevents the ubiquitination and degradation of axin.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 521.59 |
| Cas No. | 838818-26-1 |
| Formula | C29H23N5O3S |
| Solubility | ≥26.1 mg/mL in DMSO with gentle warming; insoluble in H2O; insoluble in EtOH |
| Chemical Name | 2-(3-((4-(4-methoxyphenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)propyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione |
| SDF | Download SDF |
| Canonical SMILES | O=C1N(CCCSC2=NN=C(C3=CC=NC=C3)N2C4=CC=C(OC)C=C4)C(C5=CC=CC6=CC=CC1=C56)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Description | WIKI4 is a novel inhibitor of Tankyrase with IC50 value of 15 nM for TNKS2. | |||||
| Targets | TNKS2 | |||||
| IC50 | 15 nM | |||||
Quality Control & MSDS
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Chemical structure
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