WAY 316606
Catalog No.
A3932
sFRP-1 inhibitor
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WAY 316606 (CAS 915759-45-4) is a selective small molecule inhibitor targeting secreted frizzled-related protein 1 (sFRP-1), an endogenous antagonist of Wnt signaling. WAY 316606 binds specifically to sFRP-1 (Kd = 0.08 μM), reducing its inhibitory effect and thus activating the canonical Wnt pathway. In cell-based reporter assays using U2-OS osteosarcoma cells, WAY 316606 dose-dependently promoted Wnt signaling with an EC50 of 0.65 μM. Ex vivo studies with neonatal murine calvarial tissue further demonstrated that WAY 316606 enhances osteoblast activity and bone formation. This compound serves as a research tool for investigating Wnt-associated bone metabolism and therapeutic strategies for metabolic bone disorders.
- 1. Gary Ka-Wing Yuen, Bryan Siu-Yin Ho, et al. "Tectoridin Stimulates the Activity of Human Dermal Papilla Cells and Promotes Hair Shaft Elongation in Mouse Vibrissae Hair Follicle Culture." Molecules. 2022 Jan 8;27(2):400. PMID:35056713
- 2. Zhu F, Li H, et al. "miR-155 antagomir protect against DSS-induced colitis in mice through regulating Th17/Treg cell balance by Jarid2/Wnt/β-catenin." Biomed Pharmacother. 2020;126:109909. PMID:32135463
- 3. Hawkshaw NJ, Hardman JA, et al."Identifying novel strategies for treating human hair loss disorders: Cyclosporine A suppresses the Wnt inhibitor, SFRP1, in the dermal papilla of human scalp hair follicles." PLoS Biol. 2018 May 8;16(5):e2003705. PMID:29738529
| Storage | Store at -20°C |
| M.Wt | 448.48 |
| Cas No. | 915759-45-4 |
| Formula | C18H19F3N2O4S2 |
| Synonyms | WAY-316606;WAY316606 |
| Solubility | ≥44.8 mg/mL in DMSO with ultrasonic; insoluble in H2O; ≥6.26 mg/mL in EtOH with gentle warming and ultrasonic |
| Chemical Name | 5-(benzenesulfonyl)-N-piperidin-4-yl-2-(trifluoromethyl)benzenesulfonamide |
| SDF | Download SDF |
| Canonical SMILES | C1CNCCC1NS(=O)(=O)C2=C(C=CC(=C2)S(=O)(=O)C3=CC=CC=C3)C(F)(F)F |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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